| A | B |
| 1901 | Jacobus Henricus Van't Hoff (chemical dynamics and osmotic pressure) |
| 1902 | Hermann Emil Fischer (sugar and purine synthesis) |
| 1903 | Svante August Arrhenius (electrolytic theory of dissociation) |
| 1904 | Sir William Ramsay (noble gases) |
| 1905 | Johann Friedrich Wilhelm Adolf von Baeyer (organic dyes and hydroaromatic compounds) |
| 1906 | Henri Moissan (fluorine and electric furnace) |
| 1907 | Eduard Buchner (cell free fermentation) |
| 1908 | Lord Ernest Rutherford (chemistry of radioactive substances) |
| 1909 | Wilhelm Ostwald (catalysis, chemical equilibria, and reaction rates) |
| 1910 | Otto Wallach (alicyclic compounds) |
| 1911 | Marie Curie (radium and polonium) |
| 1912 | Victor Grignard (Grignard reagent) and Paul Sabatier (hydrogenating organic compounds in the presence of finely disintegrated metals) |
| 1913 | Alfred Werner (linkage of atoms in molecules) |
| 1914 | Theodore William Richards (accurate determinations of various atomic weights) |
| 1915 | Richard Martin Willstatter (plant pigments, especially chlorophyll) |
| 1916 | NONE |
| 1917 | NONE |
| 1918 | Fritz Haber (synthesis of ammonia) |
| 1919 | NONE |
| 1920 | Walther Hermann Nernst (thermochemistry) |
| 1921 | Frederick Soddy (nature of isotopes) |
| 1922 | Francis William Aston (discovery of isotopes, and "whole-number" rule) |
| 1923 | Fritz Pregl (micro-analysis of organic substances) |
| 1924 | NONE |
| 1925 | Richard Adolf Zsigmondy (heterogenous nature of colloid solutions) |
| 1926 | The (Theodor) Svedberg ("disperse systems") |
| 1927 | Heinrich Otto Wieland (bile acids) |
| 1928 | Adolf Otto Reinhold Windaus (sterols and vitamins) |
| 1929 | Sir Arthur Harden and Hans Karl August Simon Von Euler-Chelpin (fermentation of sugars) |
| 1930 | Hans Fischer (synthesis of haemin and work on haemin and chlorophyll) |
| 1931 | Carl Bosch and Friedrich Bergius (chemical high pressure methods) |
| 1932 | Irving Langmuir (surface chemistry) |
| 1933 | NONE |
| 1934 | Harold Clayton Urey (heavy hydrogen) |
| 1935 | Frederic Joliot and Irene Joliot-Curie (synthesis of new radioactive elements) |
| 1936 | Petrus (Peter) Josephus Wilhelmus Debye (dipole moments and x-ray diffraction in gases) |
| 1937 | Sir Walter Norman Hayworth (carbohydrates and vitamin C) and Paul Karrer (carotenoids, flavins, and vitamins A and B2) |
| 1938 | Richard Kuhn (carotenoids and vitamins) |
| 1939 | Adolf Friedrich Johann Butenandt (sex hormones) and Leopold Ruzicka (polymethylenes and higher turpenes) |
| 1940 | NONE |
| 1941 | NONE |
| 1942 | NONE |
| 1943 | George de Hevesy (using isotopes as tracers in study of chemical processes) |
| 1944 | Otto Hahn (fission of heavy nuclei) |
| 1945 | Artturi Ilmari Virtanen (fodder preservation method) |
| 1946 | James Batcheller Sumner (discovered that enzymes can be crystallized) and John Howard Northrop and Wendell Meredith Stanley (preparation of pure enzymes and viral proteins) |
| 1947 | Sir Robert Robinson (plant products of biological importance, especially the alkaloids) |
| 1948 | Arne Wilhelm Kaurin Tiselius (complex nature of serum proteins) |
| 1949 | William Francis Giauque (behavior of substances at extremely low temperatures) |
| 1950 | Otto Paul Hermann Diels and Kurt Alder (diene synthesis) |
| 1951 | Edwin Mattison McMillan and Glenn Theodore Seaborg (transuranium elements) |
| 1952 | Archer John Porter Martin and Richard Laurence Millington Synge (partition chromatography) |
| 1953 | Hermann Staudinger (macromolecular chemistry) |
| 1954 | Linus Carl Pauling (nature of the chemical bond) |
| 1955 | Vincent du Vigneaud (first synthesis of a polypeptide hormone) |
| 1956 | Sir Cyril Norman Hinshelwood and Nikolay Nikolaevich Semenov (mechanism of chemical reactions) |
| 1957 | Lord Alexander R. Todd (nucleotides and nucleotide co-enzymes) |
| 1958 | Frederick Sanger (structure of insulin) |
| 1959 | Jaroslav Heyrovsky (polarographic methods of analysis) |
| 1960 | Willard Frank Libby (carbon dating) |
| 1961 | Melvin Calvin (carbon dioxide assimilation in plants) |
| 1962 | Max Ferdinand Perutz and Sir John Cowdery Kendrew (structures of globular proteins) |
| 1963 | Karl Ziegler and Giulio Natta (chemistry and technology of high polymers) |
| 1964 | Dorothy Crowfoot Hodgkin (X-ray structures of important biochemical substances) |
| 1965 | Robert Burns Woodward (organic synthesis) |
| 1966 | Robert S. Mulliken (structure based on molecular orbital method) |
| 1967 | Manfred Eigen, Ronald George Wreyford Norrish, and Lord George Porter (extremely fast chemical reactions) |
| 1968 | Lars Onsager (reciprocal relations bearing his name, fundamental to thermodynamics of irreversible processes) |
| 1969 | Sir Derek H. R. Barton and Odd Hassel (concept of conformation and its application in chemistry) |
| 1970 | Luis F. Leloir (sugar nucleotides) |
| 1971 | Gerhard Herzberg (electronic structure and geometry of molecules) |
| 1972 | Christian B. Anfinsen, Stanford Moore, and William H. Stein (structure and function of ribonuclease) |
| 1973 | Ernst Otto Fischer and Sir Geoffrey Wilkinson (organometallic "sandwich" compounds) |
| 1974 | Paul J. Flory (physical chemistry of the macromolecules) |
| 1975 | Sir John Warcup Cornforth (stereochemistry of enzyme-catalyzed reactions) and Vladimir Prelog (stereochemistry of organic molecules and reactions) |
| 1976 | William Lipscomb (structure of boranes) |
| 1977 | Ilya Prigogine (theory of dissipative structures) |
| 1978 | Peter D. Mitchell (chemiosmotic theory) |
| 1979 | Herbert C. Brown and Georg Wittig (use of boron- and phosphorus-containing compounds, respectively) |
| 1980 | Paul Berg (recombinant DNA) and Walter Gilbert and Frederick Sanger (DNA sequencing) |
| 1981 | Kenichi Fukui and Roald Hoffman (theories on the course of chemical reactions) |
| 1982 | Sir Aaron Klug (crystallographic electron microscopy) |
| 1983 | Henry Taube (electron transfer reactions) |
| 1984 | Robert Bruce Merrifield (chemical synthesis on a solid matrix) |
| 1985 | Herbert A. Hauptman and Jerome Karle (determination of crystal structures) |
| 1986 | Dudley R. Herschbach, Yuan T. Lee, and John C. Polanyi (dynamics of chemical elementary processes) |
| 1987 | Donald J. Cram, Jean-Marie Lehn, and Charles J. Pedersen (molecules with structure-specific interactions of high selectivity) |
| 1988 | Johann Deisenhofer, Robert Huber, and Hartmut Michel (3D structure of a photosynthetic reaction center) |
| 1989 | Sidney Altman and Thomas R. Cech (catalytic properties of RNA) |
| 1990 | Elias James Corey (organic synthesis) |
| 1991 | Richard R. Ernst (high resolution NMR) |
| 1992 | Rudolph A. Marcus (electron transfer reactions in chemical systems) |
| 1993 | Kary B. Mullis (PCR) and Michael Smith (oligonucleotide-based, site-directed mutagenesis) |
| 1994 | George A. Olah (carbocation chemistry) |
| 1995 | Paul Crutzen, Mario Molina, F. Sherwood Rowland (formation and decomposition of ozone) |
| 1996 | Robert F. Curl, Jr., Sir Harold W. Kroto, and Richard E. Smalley (discovery of fullerenes) |
| 1997 | Paul D. Boyer and John E. Walker (synthesis of ATP) and Jens C. Skou (Na+, K+-ATPase) |
| 1998 | Walter Kohn (density-functional theory) and John A. Pople (computational methods in quantum chemistry) |
| 1999 | Ahmed H. Zewail (using lasers to show atoms moving during a reaction) |