| A | B |
|---|
| THE COMPLEMENT SYSTEM CONSISTS OF ____ PLASMA ____. | 30 / PLASMA |
| COMPLEMENT PROTEINS ARE PRODUCED BY THE ___ AND ENTER THE BLOOD IN AN INACTIVE FORM | LIVER |
| COMPLEMENT PROTEINS INCLUDE: | C1 - C9 PLUS FACTOR B, FACTOR D, & PROPERDIN |
| THE 3 PATHWAYS BY WHICH COMPLEMENT PROTEINS CAN BE ACTIVATED ARE: | CLASSICAL, ALTERNATIVE, LECTIN |
| BRIEFLY DESCRIBE ACTIVATION OF COMPLEMENT BY THE CLASSICAL PATHWAY. | ANTIGEN-ANTIBODY REACTION ACTIVATES C3, WHICH IN TURN ACTIVATES THE ENTIRE SYSTEM |
| BRIEFLY DESCRIBE ACTIVATION OF COMPLEMENT BY THE ALTERNATIVE PATHWAY. | POLYSACCHARIDES IN THE CELL WALLS OF CERTAIN MICROBES & SOME FOREIGN BLOOD CELLS INTERACT WITH FACTOR B, FACTOR C, & PROPERDIN. THIS ACTIVATES C3. |
| BRIEFLY DESCRIBE ACTIVATION OF COMPLEMENT BY THE LECTIN PATHWAY. | AFTER PHAGOCYTIZING INVADERS, MACROPHAGES PRODUCE LECTINS, ONE OF WHICH BINDS TO MANNOSE (A SUGAR) ON THE OUTSIDE OF BACTERIA OR VIRUSES. THIS ACTIVATES C 2 & C4, WHICH ACTIVATE C3. |
| ACTIVATION OF THE COMPLEMENT SYSTEM CAUSES 3 PROCESSES THAT HELP DESTROY MICROBES: | CYTOLYSIS (BY MAC), INFLAMMATION, OPSONIZATION |
| A BODY DEFENSE AGAINST VIRUSES IS PRODUCTION OF ___ BY VIRUS-INFECTED CELLS. | INTERFERONS |
| INTERFERONS CANNOT SAVE THE VIRUS-INFECTED CELL, BUT THEY DO HELP IN WHAT WAY? | PROTECT NEIGHBORING CELLS FROM VIRUS |
| INTERFERONS ARE ___ SPECIFIC BUT NOT ___ SPECIFIC. | SPECIES / VIRUS |
| NAME THE 3 TYPES OF HUMAN INTERFERONS. | ALPHA, BETA, GAMMA |
| USES OF INTERFERONS INVOLVE TREATMENT OF: | CERTAIN VIRAL DISEASES & SLOWING PROGRESSION OF MULTIPLE SCLEROSIS |
| DRAWBACKS IN USE OF INTERFERONS INCLUDE: | TOXICITY & MALAISE (FEELING AWFUL) |
