Sapere and Conoscere both mean "to know".

Here are the conjugations of both verbs:

sapere = to know
Io so = I know
Tu sai = you know
Lui/lei sa = he/she knows
Noi sappiamo = we know
Voi sapete = you (plural) know
Loro sanno = they know

Conoscere = to know
Io conosco = I know
Tu conosci = You know
Lui/lei conosce = he/she knows
Noi conosciamo = we know
Voi conoscete = you (plural) know
Loro conoscono = they know

These verbs both mean "to know" but not in the same sense.

Sapere is used for knowing facts and information, and to know how to do something.

Examples: I know how to cook = So cucinare
I know where he lives = So dove abita.
I know his name. = So come si chiama.

Conoscere is used to know people, places, famous people, works of art, songs, etc.

Examples: I know Marco = Conosco Marco.
I know Rome = Conosco Roma.
I know this restaurant = Conosco questo ristorante.


To express that you know how to do something, take the congugated form of sapere and then add any infinitve you need:

they know how to drive = Sanno guidare
we know how to speak Italian. = sappiamo parlare italiano.