| A | B |
| Known for his agriculturally and economically successful missions | Fr. Junipero Serra |
| Wealthy heiress who used her money fund religious orders in the frontier church who served many native Americans, immigrants, and slaves. | Katherine Drexel |
| Widow, Ursuline sister, and missionary to the Italian immigrants. | Frances Cabrini |
| First native American to be called “blessed” | Kateri Takakwitha |
| First bishop of the newly founded United States | John Carroll |
| African American who was prohibited from attending seminaries in the United States, the first black priest ordained in the U.S. | Augustus Tolton |
| First U.S.-born person declared a saint, and the founder of the U.S. Catholic school system. | Elizabeth Ann Seton |
| Movement that fueled anti-Catholic bigotry | nativitism, the Know Nothing Party |
| Presidential candidate defeated in large part because of his Catholic faith | Alfred E Smith |