The ability to monitor the formation of a blood clot in whole blood can be used to rapidly establish whether there is a defect in plasma coagulation factors, fibrinogen concentration and/or platelet count. The ROTEM assays
Parameter Definition Information
Clotting Time CT (sec) Time to reach 2mm amplitude from beginning of test Speed of fibrin formation; influenced by clotting factors, anti-coagulants
Clot Formation Time CFT (sec) Time to reach 20mm amplitude from the time of 2mm amplitude Kinetics of clot formation; influenced by platelet level / function and fibrinogen level / ability to polymerize
Maximum Clot Firmness, MCF Maximum amplitude (in mm) Firmness of clot, i.e., clot quality; influenced by platelets, fibrinogen (concentration and ability to polymerize), Factor XIII, fibrinolysis
Maximum Lysis, ML (% of MCF) Percent of clot firmess lost during measurement Abnormal ML at 30 minutes likely indicates fibrinolysis
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