| A | B |
| Prince Henry | Portuguese leader who started a school for navigators |
| Giovanni Caboto | Italian explorer who landed in present-day Newfoundland but told people he had found Cathay |
| Ferdinand Magellan | European who proved it was possible to reach Asia by sailing west from Europe |
| Leif Eriksson | leader of the first Europeans to visit the Americas |
| Pacific Ocean | body of water reached by Spanish explorer Vasco Nunez de Balboa |
| Constantinople | city captured by the Turks, closing off trade routes between Europe and Asia |
| Vikings | first European people known to have visited the Americas |
| Vinland | name of the first European settlement in the Americas |
| Vasco da Gama | Portuguese ecplorer who found a sea route to Asia by sailing around Africa |
| Martin Behaim | First European to make a globe |
| Amerigo Vespucci | Italian explorer who figured out that Columbus had not reached Asia |
| Guanahani | local name for the island on which Columbus first landed |
| Marco Polo | European whose descriptions of the riches of China made traders want to go to Asia |
| Bartholomeu Dias | Portuguese explorer who was the first European to sail around the southern tip of Africa |
| Atahuallpa | leader of Incas killed by the Spanish |
| Africans | peoples brought to te Americas against their will and forced to work for the colonists |
| Motecuhzoma | Aztec leader when Europeans came to Mexico |
| Tisquantum | Indian who taught the Pilgrims how to fish and plant crops that would do well |
| Francisco Pizarro | Spanish conquistador who ordered his soldiers to kill the Inca emperor |
| Sir Walter Raleigh | European who founded a colony at Roanoke that soon disappeared |
| Hernando de Soto | explorer who claimed all of what is today the southeastern United States for Spain |
| Samuel de Champlain | explorer who founded Quebec and Montreal |
| Hernando Cortes | leader of the Spanish conquistadors who conquered the Aztecs |
| Native Americans | peoples who died from hunger, overwork, and diseases after being enslaved by the Spanish |
| Jacques Cartier | Explorer who looked for Northwest Passage |
| Juan Ponce de Leon | Spanish explorer who looked for the Fountain of Youth and named present-day Florida |
| missionaries | people who came to the Americas to convert native peoples to Christianity |
| Francisco Vasquez de Coronado | Spanish explorer who heard stories about the Seven Cities of Gold and set out to find them |