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Drugs Affecting the Central and Peripheral Nervous Systems

A fun way to learn pharmacology

AB
Central Nervous SystemComposed of a brain and spinal cord
SynapseA microscopic gap that separates neurons
Neurotransmitter substancesAcetylcholine, catecholamines, histamine, serotonin, endorphins, and enkephalins
Cerebral cortexInvolved in all conscious processes
ThalamusReceives impulses carrying sensations such as heat, cold, pain, muscle position
HypothalamusRegulates body temperature, arterial blood pressure, anterior pituitary hormones, food and water intake
Medulla oblongataContains neurons that form the vital cardiac, respiratory, and vasomotor centers
Reticular formationWhen stimulated produces wakefulness and alertness
Limbic systemRegulates behavior and emotions
CerebellumCoordinates muscular activity; maintains balances and posture
Pyramidal tractsCarry impulses from the brain to the spinal cord to the skeletal muscle
Extrapyramidal tractsDoes not enter the pyramids
HypoxiaLack of oxygen
HypoglycemiaCauses confusion, dizziness, convulsions, loss of consciousness, and brain damage
ThiamineRequired for the production and utilization of glucose
Thiamine deficiencyCauses degeneration of the myelin sheath
Moderate CNS depressionCauses drowsiness, decreased muscle tone, decreased ability to move, decreased perception of sensation
Severe CNS depressionCauses unconsciousness, respiratory failure
Mild CNS stimulationCauses wakefulness, alertness, decreased fatigue
Moderate CNS stimulationProduces hyperactivity, excessive talking, nervousness, insomnia
PhenobarbitalProduces side effects of apnea, laryngospasm
PhenytoinProduces side effects of hirutism, gingival hyperplasia
DiazepamProduces side effects of ataxia, drowsiness
EthosuximideProduces side effects of hiccups, headaches
NardilMAO Inhibitor
ProzacTricyclic antidepressant
EskalithLithium
ChlorpromazinePhenothiazine derivative
AmitriptylineTricyclic antidepressant
Muscarinic receptorsLocated in smooth muscle, cardiac muscle, and glands of parasympathetic fibers and effector organs of the cholinergic sympathetic fibers
Nicotinic receptorsLocated in the ganglia of both parasympathetic and sympathetic fibers, the adrenal medulla, and the skeletal muscle that is supplied by the somatic motor system
Alpha 1 sitesOn the postsynaptic effector cells
Alpha 2 sitesOn the presynaptic nerve terminals
Synaptic junctionFrom one neuron to another neuron
Neurohormonal transmissionPassage of a nerve impulse across a junction with the use of a chemical
ConductionPassage of a nerve impulse along a nerve fiber or muscle fiber
Neuroeffector junctionFrom a neuron to an effector organ
Adrenergic blocking drugBlocks the action of the sympathetic nervous system
Cholinergic blocking drugBlocks the action of the parasympathetic nervous system
Cardiac muscleAlpha 1 receptor
Bronchial smooth muscleBeta 2 Receptor
Adipose TissueBeta 2 Receptor
Platelet aggregationAlpha 2 Receptor
LevodopaThe most effective drug available for treatment of Parkinson's Disease
DantroleneDrug for prevention and treatment of malignant hyperthermia
DiazepamPhysically incompatible with othe drugs of this class
HalothaneOne of the most widely used anesthetics
Thiopental sodiumGiven intravenous to induce anesthesia
PancuroniumIts effects can be reversed by neostigmine
Nitrous oxideUsed alone for analgesia in dentistry, obstetrics, and brief surgical procedures
FentanylA very potent narcotic analgesic similar to morphine whose analgesic effect lasts about 30 minutes
LidocaineTopical anesthetic that has a rapid onset
AlcoholThe primary drug of abuse worldwide
MarijuanaDrug used as an antiemetic for patients receiving anticancer drugs
DisulfiramA drug used in the treatment of alcohol abuse
MethadoneDrug used in the treatment of heroin abuse
DopamineA drug used to raise the blood pressure
Narrow-angle glaucomaA contraindication to using adrenergic agents
IsoproterenolA drug that produces bronchodilation as well as tachycardia
EpinephrineA drug used for the treatment of allergic reactions, shock, and cardiac arrest
AlbuterolCommonly used inhaler that produces bronchodilation
LabetalolThe drug of choice for treating hypertensive emergencies
AtenololA selective beta blocker used to treat a myocardial infarction
PropranololPatients use this drug to prevent migraine headaches
DigoxinWhen this drug is administered with beta blockers, heart block can result
PrazosinThis drug can be administered with beta blockers for treatment of unresponsive hypertension
IsoproterenolWhen this drug is administered concurrently with beta adrenergic blockers, it will decrease the effect of the beta adrenergic blocking agent


Kathy Mauser

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