| A | B |
|---|
| hereditary angioneurotic edema | C1INH DEFICIENCY; INCREASED FORMATION OF BRADYKININ |
| PAROXYSMAL NOCTURNAL HEMOGLOBINURIA | PHOSPHATIDYLINOSITOL MUTATION; COMPLEMENT OVERACTIVATION |
| C3 DEFICIENCY | FATAL SUSCEPTIBILTY TO INFECTIONS |
| C2 C4 | SYSTEMIC LUPUS ERYTHEMATOUS |
| NO MAC FORMATION | NEISSERIA INFECTIONS DEFICIENCIES IN LATE COMPONENTS OF COMPLEMENT |
| LAD-1 | BETA-CHAIN OF CD11/CD18 INTEGRINS |
| LAD-2 | SELECTIN RECEPTOR NOT SYNTHESIZED; SIAYLATED/FUCOSYL TRANS. |
| CHRONIC GRANULOMATOUS DISEASE | X-LINKED DECREASED OXIDATIVE BURST; NADPH OXIDASE MEMBRANE |
| CHRONIC GRANULOMATOUS DISEASE | (AR) DECREASED OXIDATIVE BURST; NADPH OXIDASE CYTOPLASMIC |
| MYELOPEROXIDASE DEFICIENCY | ABSENT MPO-H2O2 SYSTEM |
| CHEDIAK-HIGASHI SYNDROME | PYOGENIC BAC. LYST MUTATION |
| THERMAL INJURY | CHEMOTAXIS |
| DIABETES | CHEMOTAXIS |
| MALIGNANCY | CHEMOTAXIS |
| SEPSIS | CHEMOTAXIS |
| IMMUNODEFICIENCIES | CHEMOTAXIS |
| HEMOLDIALYSIS | ADHESION |
| DIABETES MELITUS | ADHESION |
| LEUKEMIA | PHAGOCYTOSIS AND MICROBICIDAL ACTIVITY |
| ANEMIA | PHAGOCYTOSIS AND MICROBICIDAL ACTIVITY |
| SEPSIS | PHAGOCYTOSIS AND MICROBICIDAL ACTIVITY |
| DIABETES | PHAGOCYTOSIS AND MICROBICIDAL ACTIVITY |
| NEONATES | PHAGOCYTOSIS AND MICROBICIDAL ACTIVITY |
| MALNUTRITION | PHAGOCYTOSIS AND MICROBICIDAL ACTIVITY |
| Toll-like Receptor Signaling Defects | Defects in TLR (frequently TLR4) and CD40 compromise NF-κB activation |
| Anhidrotic Ectodermal Dysplasia with Immunodeficiency (EDA-ID) X-LINKEd | malformation of ectoderm-derived is; IKKγ mutation; encap. |
| (EDA-ID) (AUTOSOMAL RECESSIVE) | IκBα – impaired NF-κB activation; recurrent infection |
| SCID- AR forms | low T/Ig; defect in cytokines;Mutations in IL-2Rα chain; IL-7Rα chain;and/or JAK3 |
| X-linked SCID | LOW T/Ig; defect in cytokines;γ chain mutations;Defective T cell w/o IL-7 |
| ADA Deficiency | BAD NUCLEOTIDE Salvage; TOXIN ACCULM |
| PNP Deficiency | defect nuc. Salvage; toxic acculm./lymphocytes |
| RAG1/RAG2 Deficiency | DEFECTIVE CLEAVAGE V(D)J recomb; |
| ARTEMIS Defect | UNRES. HAIRPIN IN V(D)J recomb; Mut. ARTEMIS; low/ab/def t/b/ig |
| Defective pre-TCR Checkpoint | low T Ig; SCID: def.thymus dev.;MUTANTCD45/CD3δ/CD3ε/Orai1 |
| Defective pre-TCR Checkpoint | low T Ig; SCID: def.thymus dev.;MUTANTCD45/CD3δ/CD3ε/Orai1 |
| DiGeorge Syndrome | def thymus dev.; 22q11 deletion; T-box-1(TBX1) mutations |
| SYSTEMIC LUPUS E. | DNA/NUCLEOPROTEINANTIGEN |
| POLYARTERITIS NODOSA | HEP. B VIRUS SURFACE ANTIGEN |
| POSTSTREP GLOMERULONEPHRITIS | M-protein ab-antigen complex |
| CHRONIC DTH | FIBROSIS |
| T1D | MACS AND LYMPHOCYTES IN ISLETS |
| T1D | ANTIGEN: GLUTAMIC ACID DECARB., INSULIN |
| MULTIPLE SCLEROSIS | MYELIN BASIC PROTEIN |
| R.A. | TNF ANTAGONIST BENEFICAIL TX |
| RHEMATOID ARTHRITIS | SYNOVIAL JOINT ANTIGEN |
| IBS,ULCERATIVE COLITIS | ANTIGEN: INTESTINAL FLORA |
| GUILLAIN-BARRE SYNDROME | P2 OF PERIPHERAL NERVE MYELIN |
| A.I. NEPHROCARDITIS | ANTIGEN:MYOCARDIAL PROTEINS |
| CONTACT SENSITIVITY | NEOANTIGEN= ANTIGEN + SELF-PROTEIN |
| IBS | NOD2 MUTATION |
| PRE-TCR CHECKPOINT | DEFECTIVE THYMUS |
| X-LINKED SCID | DEF. IL-7; GAMMA CHAIN MUT |
| AR SCID | IL-2,7 RALPHA AND JAK3 MUT |
| RETICULAR DYSGENESIS | LOW T, B & MYELOID CELLS |
| TLR/CD40 DEFECTS | IRAK2/NEMO/ RUIN NF-kB |
| LAD1 | BAC + FUNGAL, B2-CD18 INTEGRIN |
| AGAMMAGLOBULINEMIA XLA | BTK, FAILED B MATURATION |
| ICF | DNMT3B, HYPOGAMMAGLOBULIN |
| CVID | ICOS,TACI, HYPOGAMAGLOBULIN |
| HYPER IgM | CD40, LOW WBC ACTIVATION |
| HYPER IgM | NO SOMATIC RECOMB. OR CLASS SWITCHING |
| AR AGAMMAGLOBULINEMIA | PRE-B CHECK POINT BLNK, IgALPHA |
| COMMON GAMMA CHAIN MUT. | X LINKED SCID |
| HIV | DEPLETION OF CD4+ CELLS |
| PROTEIN-CAL. MALNUTRITION | IMPAIRED LYMPHOCYTES |
| CHEMO/RADIATION | DEC. BONE MARROW PRECURSORS |
| LEUKEMIA,BM CANCER | REDUCED SITE FOR WBC DEV. |
| TRANSPLANTS, AI DISEASE | DEC. LYMPHCYT ACTIVATION |
| REMOVAL OF SPLEEN | DEC. PHAGOCYTOSIS |
| BARE LYMPHOCYTE SYN. | DEFECTIVE MHC EXPRESSION |
| MHC CLASS I DEFICIENCY | TAP1, 2 MUT;REDUCED CD8+ |
| PROXIMAL TCR SIGNAL DEFECTS | CD3,45 MUT; CMI, TdHI DEFECTS |
| WISKOTT-ALDRICH | WASP, CYTOKINESIS DEFECT |
| PERFORIN DEFICIENCY | UNCONTRL. MAC & CTL ACTIVATION |
| GRANULE FUSION DEFECTS | BAD CYTOTOX GRAN. EXOCYTOSIS |
| XL LYMPHOPROLIFERATIVE SYND. | EBV INDUCED B-CELL, SAP GENE |
| pemphigus vulgaris | AB med. proteolysis of cadherin |
| AI hemolytic anemia | opsonin & phagocytosis of rbc |
| AI thrombocytopenic purpura | opsonin+ phagocytosis/platelets |
| acute rhematic fever (ARF) | strep M-protein |
| Tuberculosis | acid-fast bacilli |
| Leprosy | Acid-fast bacilli in macrophages |
| Syphilis | Treponema pallidum |
| Cat-scratch disease | Gram-negative bacillus |
| Tuberculosis | caseating tubercle:central amorphous granular debris;loss of all cellular detail |
| Leprosy | non-caseating granulomas |
| Syphilis | Gumma:microscopic to grossly visible lesion;enclosing wall of histiocytes |
| Cat-scratch disease | Rounded or stellate granuloma containing central granular debris and recognizable neutrophils |
| Syphilis | plasma cell infiltrate; central cells are necrotic without loss of cellular outline |
