| A | B |
|---|
| Pre-B cell | cytoplasmic mu heavy chain and pre-B receptor |
| Immature B cell | Membrane IgM |
| Mature B cell | Membrane IgM, IgD |
| Activated B cell | Low rate Ig sec.; heavy chain isotype switching; affinity maturation |
| Antibody secreting cell | High rate Ig secretion; reduced membrane Ig |
| IgA | Mucosal Immunity |
| IgD | Naive B cell antigen receptor |
| IgE | Defense against helminthic parasites |
| IgG | Opponization of complement activation, |
| IgM | Naive B cell antigen receptor |
| Binds macromolecules and small chemicals | Immunoglobulin (Ig) |
| Made up of three CDRs in V-alpha and three CDRs in V-beta | T cell receptor (TCR) |
| Binds peptide-MHC complexes | T cell receptor (TCR) |
| Peptide-binding cleft made of alpha-1 and alpha-2 (class I) or alpha-1 and beta-1 (class II) | MHC molecules |
| Binds peptides | MHC molecules |
| two layers of beta-pleated sheet, held together with disulfide bonds | Ig domain |
| constant regions of the heavy chain that mediate effector functions | carboxy-terminal constant (C) regions of antibody heavy and light chains |
| variable regions that participate in antigen recognition | amino-terminal variable (V) regions of antibody heavy and light chains |
| allotope | Polymorphisms within conserved Ig amino acid sequences |
| allotype | Protein product of a distinct allelic form of an Ig gene. |
| DETERMINANT | epitope |
| HLAs | human leukocyte antigens; MHCs on human cells |
| epitope | specific portion of an antigen to which antibody binds |
| specific portion of an antigen to which antibody binds | determinant |
| F(ab')2 | retains bivalent;used in research |
| Fab | retains monovalent; used in research |
| Fc | proteolytic fragment of Ig containing only the s-s c-terminal regions of the two heavy chains |
| Fc receptor | rcptr for c-terminal region of Ig |
| ADCC | NK targets Ig coated cells for lysis; Fc(gamma)RIII |
| antiserum | serum w/antibody to antigen |
| affinity maturation | somatic mutation of Ig genes |
| hinge region | flexible regions between Ch1 and 2 in some Ig molecules; |
| CDRs | antigen-binding; 3 hypervariable regions |
| hypervariable segments | 3 loops connect adjacent B-sheets |
| Kabat-Wu plot | histogram depitcting # of different aa res/Ig light chains |
| BiP, calnexin | nacent Ig chaperones |
| antibody specific for one antigen, produced by a hybridoma; used in research and diagnosis | monoclonal antibody |
| M-cells | specialized epithelial cells; Peyer's; Ig transport |
| polyvalence | multiple identical copies of epitope/ one antigen; |
| Poly-Ig recpetor | Fc receptor expressed by mucosal epithelia; |
| Polyclonal activators | agents capable of activating many clones of lymphocytes, regardless of their specificity |
| Poly-Ig recpetor | transpt of IgA and IgM through epithelium into intestinal lumen |
| IgE | immediate hypersensitivity |
| IgG | anti-body dep. cell mediated cytotoxicity |
| IgG | feedbk inhib. of B cells |
| IgG | neonatal immunity |
| Polyclonal activators | anti-IgM antibodies for B cells, anti-CD3 abs, bacterial superantigens, PHA for T-cells |
| CDRs | complementarity determining region) |
| affinity maturation | leads to increased affinity of antibody for an antigen |
| affinity maturation | concurrent w/humoral response |
| affinity maturation | germinal centers of lymph nodes |
