| A | B |
|---|
| IL-1 | pyrogen - mediator of acute phase response;activates IL-6 IL-2R IL-8 adhesion molecules |
| IL-2 | T cell proliferation (mainly CD4 in autocrine manner) activates IFN-gamma IL-6 NK cell growth |
| IL-3 | expansion of bone marrow progenitor cells |
| IL-4 | inhibits other inflammatory cytokines IgE isotype switching MHC II in B cells TH0-->TH2 |
| IL-5 | increases eosinophils B cell growth and differentiation IgE production (with IL-4) |
| IL-6 | mediatory of acute phase response activates B cell growth and differentiation increased by TNF & IL-1 |
| IL-7 | increases IL-2 IL-2R |
| IL-8 | chemoattractant and activator of neutrophils |
| IL-9 | increases IL-6 from eosinophils |
| IL-10 | inhibits other inflammatory cytokines suppresses TH1 response inhibits IL-17 actions |
| IL-11 | increases IL-4 inhibits IFN-γ |
| IL-12 | increases IFN-γ major initator of TH1 response decreases TNF increases B cells and MHC II expression |
| IL-13 | inhibits inflammatory cytokines increases B cell growth |
| IL-14 | proliferation of ACTIVE B cells |
| IL-15 | T cell proliferation activation of NKs B cells and essential for prolonged inflammation; maintains MEMORY cells |
| IL-16 | chemotaxis of CD4+ T cells and eosinophils |
| IL-17 | maintains inflammation increases IL-6 |
| IL-18 | increases IFN-gamma T cell proliferation activates NK cells |
| IL-23 | similar to IL-12 but has actions on memory T cells and IL-12 |
| TNF-α | pyrogen;leading to inflammation causes release of IL-1 IL-6 and IL-8 from MΦ |
| TNF-β | not inflammatory;maintains architecture of secondary lymphoid organs |
| IFN-γ | activates mononuclear phag. increases MHC I II increased CAMs activates NK cells and neutrophils increases IL-12R on TH1s |
| IFN-α | all cells: initiates antiviral state increases MHC I expression |
| IFN-β | NK cells: activation |
| GM-CSF | increases production of granulocytes and monocytes in marrow |
| G-CSF | increases production of granulocytes especially neutrophils |
| M-CSF | acts locally to turn precursor cells into monocytes |
| TGF-α | activates epithelial and mesenchymal growth |
| TGF-β | has both activation and inhibitory effects --> inhibits T cell growth CTL activation and macrophage activation |
| TH1 cells | (IL-2 TNF IFN-γ) -activated by DC --> (DTH & CMI)activates mΦ increases Ag presentation and Fc receptor expression |
| TH2 cells | (IL-3 IL-4 IL-5 IL-10 IL13) - activated by DC --> mediates humoral responses and allergies via IgE |
