| A | B |
|---|
| cyclosporine/tacrolimus | inhibits calcineurin phosphatase |
| decreased phophorylation of NFAT | cyclosporine/tacrolimus |
| Crohn's disease | cyclosporine |
| sirolimus | blocks T-cell response to cytokines |
| azathioprine/6-mercaptopurine | decreased purine synthesis |
| mycophenolate mofetil | inh inosine monop dehydrogenase |
| methotrexate | INHIBITION OF DHFR |
| cyclophosphamide | alkylates DNA on rapidly prolife cells |
| calcineurin | key transcription for T-cells |
