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Pathology terms and cytokines

AB
B-cellsRespond to cell-free and plasma membrane-bound antigens
T-cellsRespond to cell-bound antigens
Natural-killer-cellsCell population lacking T cell receptor (TCR) and CD4 and CD8 coreceptors
MacrophagesMonocyte-derived cells
Dendritic-cellsMonocyte-derived cells (e.g.
Follicular-dendritic-cellsFound in lymphatic nodules
Effector-cellsMacrophages
plasminproteolytic enzyme present in inflammatory exudate
kinninogensvasoactive peptides generated from plasma proteins by kallikreins
bradykininvasoactive nonpeptide
effects of bradykininincreased vascular permeability
Hageman's FactorFACTOR XII of intrinsic clotting pathways
cleaves glycoprotein precursor,"high molecular weight kinniogen," to produce bradykininkallikrein
alternative pathwaycleavage of C3 in response to endotoxin, microbial LPS...cobra venom,etc...
C3 convertasesplits C3 to C3a and C3b
C3bfunctional fragment of C3; covalently attaches to complement target; then to other c-fragments to form C5-convertase
C5-convertasecleaves C5 to C5b and C5a; binds late components C6-9 together to form MAC
C5a activateslipoxygenase pathway of arachidonic acid met. in PMNs and Monocytes
C5apowerful chemotactant for neutrophils, monocytes, eoisinophils, basophils
C3b, iC3bopsonins, fix to bacterial cell wall, enhance affinity for phagocytosis
PARs (protease activated receptors)GPCRs on platelets, endothelialsm. muscle; bind various trypsin like serine proteases
engagement of PAR-1 by factor IIa triggers...mobilization of P-selectin; prod. chemokines, PAF, NO, prostaglandins;
major coagulation protease, cleaves circulating soluble fibrinogen to...thrombin; ...form insoluble fibrin clot
thrombin (factor IIa)protease; main link between coagulation and inflammation
kallikreinpotent activator of Hageman Factor; autocatalytic amplification of initial stimulus
kallikreindirectly converts C5 to chemotractant C5a
effects of complement activationincrease opsonation, chemotaxis, vascular permeability, proteolytic enzymes
lectin pathwayplasma mannose bindinig lectin binds carbs on microbes--> C1
VASOCONSTRICTIONthromboxane A2; leukotriense C4, D4, E4
VASODILATIONPGI2, PGE1, PGE2, PGD2
CHEMOTAXIS; LEUKOCYTE ADHESIONLeukotriene B4; HETE, lipotoxins
Prostaglandins, NO, HistamineVASODILATION
Increased Vascular PermeabilityVasoactive Amines, Bradykinin; C3a, C5a; PAF, leukotrienes C4,D4,E4
chemotaxis, leukocyte recruitment/activationC5a; leukotrienes B4; chemokines; IL-1; TNF;prostaglandins
tissue damagelysosomal enzymes from MACS & PMNs; ROS, NO
chemokinesincreased avidity of integrins
leukocyte diapedesis; vascular permeabiltypredominantly in venules; capillaries of lungs
1st 6-24 hours of inflammatory infiltrateneutrophils predominate
hours 24-48 of inflammatory infiltratemonocytes predominate
pre-formed, chemical mediators of inflammation in secretory granulesHISTAMINE; SEROTONIN; LYSOSOMAL ENZYMES
sources of pre-formed mediators in secretory granulesMCs; basophils; platelets; PMNs, Macs
cellular; newly synthesized chemical mediators of inflamm.prostaglandins; leukotrienes; PAF; ROS; NO; Cytokines
source of synthesized cellularallleukocytes, platelets, EC, Macs, No, Cytokines, Macs, lymphocyres
chemical mediators of inflam. from liver/plasma; Factor XII activationKinin System (bradykinin)
chemical mediators of inflam. from liver/plasma/complement activation; anaphalotoxinC3a; C5a
chemical mediators of inflam. from liver/plasma/complement activation; membrane attack complexC3b; C5b-C9
VasodilationProstaglandins
VasodilationNitric oxide
VasodilationHistamine
Chemotaxis-leukocyte-recruitment-and-activationC5a
Chemotaxis-leukocyte-recruitment-and-activationLeukotriene B4
Chemotaxis-leukocyte-recruitment-and-activationChemokines
Chemotaxis-leukocyte-recruitment-and-activationIL-1
Chemotaxis-leukocyte-recruitment-and-activationBacterial products
FeverIL-1& TNF
FeverProstaglandins
PainProstaglandins
PainBradykinin
Tissue damageNeutrophil and macrophage lysosomal enzymes
Tissue damageNitric oxide
Tissue damageOxygen metabolites
histaminemast cells, platelets
serotoninmast cells, platelets
bradykininplasma substrate, pain
C3aPlasma protien via liver, opsonic fragment
C5amacrophages, leukocyte adhesion, activation
prostaglandinsmast cells from membrane phospholipids, vasodilation, pain, fever
leukotriene B4leukocytes; leukocyte adhesion, activation
Leukotriene C4, D4, E4leukocytes, mast cells; bronchoconstriction, vasoconstriction
oxygen metabolitesleukocytes, endothelial damage, tissue damage
PAFleukocytes, mast cells; bronchoconstriction, leukocyte priming
IL-1macrophages, other; acute-phase reactions, endothelial activation
TNFmacrophages, other; acute-phase reactions, endothelial activation
Chemokinesleukocytes, other; leukocyte activation
Nitric OxideMacrophages, endothelium; vasodilation, cytotoxicity
C-reactive Protein (CRP)ACUTE PHASE PROTEINS up regulated by IL-6
FibrinogenACUTE PHASE PROTEINS up regulated by IL-6
serum almyloid A protein (SAA)ACUTE PHASE PROTEINS up regulated by IL-1 or TNF



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