| A | B |
|---|
| pre-b | µ ; pre-b rcptr |
| pre-b | recomb Hc VDJ; µ mRNA |
| Immature-B | IgM; recmb Hc: κ γ (VJ) |
| Immature-B | negative selection |
| Mature-b | alternative splicing |
| TH1 | macrophage activation |
| TH2 | eosinophils/mast cells |
| CTLS | cytotoxicity/macrophage activation |
| NK | cytotoxicity/macrophage activation |
| ADCMC | NK cells |
| NKcell | antibody depdt cell med. cytotoxicity |
| FcRS | allow overlap btwn humoral and innate |
| CD40 | CD54 |
| TH1 | IL-18 |
| TH2 | dev |
| TH1 | IFN-γ; tbet |
| TH1 | stat 4→IFN-γ ↑ th1 |
| IFN-γ | activates macrophages |
| activate-neutrophils | lymphotoxin & tnf |
| T-cell-amplification | ↑ B7 xprsn costims on MCH (B7) |
| CRC3 | antigen-binding, diversity |
| junctional diversity | +/- nucltds @ V+D or D+J |
| Rag 1/Rag 2 | cleaves exons, forms hairpin |
| N nucleotides | non-template encoded |
| P nucleotides | ARTEMIS/complementary/VDJ |
| fetal liver derived stem cells | B-1 B-cells |
| BONE MARROW DERIVED HSC | FOLLICULAR B-CELLS |
| CLP | COMMON LYMPHIOD PROGENITOR |
| NEGATIVE SELECTION | STRONG SELF ANTIGEN BINDING |
| POSITIVE SELECTION | WEAK SELF ANTIGEN BINDING |
| TdT | mediates nucleotide addition at junctions |
| PCR | detect tumor cells in blod or tissue |
| ARTEMIS | CLEAVES GERMLINE ENDS, ASYMETRICALLY |
| TdT | NON-TEMPLATE ADDITION OF NCLTDS |
| EBF-E2A-Pax5 encode | Rag1 and 2 |
| EBF-EZA-Pax 5 | B-cell committment |
| Notch-1, GATA 3 | T-cell committment |
| Pro-B to Pre-B | IgM rearrangement |
| IgA deficiency | Giardia, TACI mutation |
| ICAM | LFA-1 |
| 1-3 HOURS | C-fos |
| 4-24HRS | CD40 LIGAND |
| 3 HRS-4 DAYS | IL-2 RECEPTOR |
| 6 HRS-2 DAYS | IL-2 |
| 6 HRS-4 DAYS | DNA SYNTHESIS |
| 4DAYS- 1-2WKS | VLA-4,-5,-6 |
| DC1 USES | IL-12 |
| DC2 USES | IFN-ALPHA, -BETA |
| PRE-DC1 | GM-CSF + IL-4 + CD40L |
| DC1 MAKES | IFN-GAMMA |
| DC2 MAKES | IFN-GAMMA, IL-10 |
| CD28 | B-7 |
| CD45 | IMMUNE SYNAPSE |
| c-KIT | PRE-PRO T-CELL |
| UNIVERSAL SURVIVAL SURFACE SIGNAL | c-KIT |
| UNIVERSAL T-CELL JUICE | INTERLEUKIN-2 |
| MEDUALLARY CORTICAL JUNCTION | NEGATIVE SELECTION |
| SMP/SMP1 | EXIT GERMINAL CENTER |
| DE-ADENINE DEAMINASE | TH1 TH2 MIGRATION? |
| INCREASE IN IL-7 | CHANGE IN M/E RATIO |
