| A | B |
|---|
| Zeta-potential | net- charge on RBC due to sialic acid residues |
| Increased-sed-rate | acute inflammatory response (fibrinogen) |
| Net-positive-charge | ”fibrinogen |
| Increased-sed-rate | increased immunoglobulin synthesis |
| →AP-1 | MAP KINASES |
| →MAP-KINASES | ”Ras-GTP |
| PLCγ1-activation | →incr. Ca+2 |
| →incr.Ca+2 | →calcineurin |
| →calcineurin | →NFAT |
| PLCγ1-activation | →DAG |
| →DAG | →PKC |
| →PKC | NF-κB |
| Cyclosporine-blocks | NF-AT activation |
| Steroids-inhibit | NF-κB and AP-1(Fos/Jun) |
| NF-AT | transcription factor req. for IL-2 gene |
| NF-κB | transcription factor req. for IL-2 gene |
| AP-1(Fos/Jun) | transcription factor req. for IL-2 gene |
| c-myc | gene req. for T cell activation |
| CD40L | gene req. for T cell activation |
| IL-2R | gene req. for T cell activation |
| TAP/LMP | LOCATED ON CHROMOSOME 6 |
| Clonal-selection | germinal follicle |
| Germinal-follicle | affinity maturation |
| Memory | “peripheral |
| CD44 | LEUKOCYTE HOMING |
| CD25 | IL-2 RECEPTOR |
| CD3 | PART OF TCR COMPLEX |
| CD4 | MHC-II CORECEPTOR |
| CD8 | MHC-I CORECEPTOR |
| Chromosome-14 | Heavy chain genes |
| Ig-κ | Chromosome 2 |
| Ig-λ | Chromosome 22 |
| DC1 | myeliod IL-12+++ |
| DC2 | lymphoid Il-12+/- |
| early-IL-4 | DC1;IL-12;Th1 |
| persistent-IL-4 | DC2;Th1;Th2 |
| SIALOMUCINS | GlyCAM-1 CD34 |
| CCL19 | produced by HEV |
| MadCAM | PEYER’S L-selectin ligand |
| pre-b | recomb Hc VDJ; µ mRNA |
| Immature-B | IgM; recmb Hc: κ γ (VJ) |
| Immature-B | negative selection |
| Mature-b | alternative splicing |
| TH1 | macrophage activation |
| TH2 | eosinophils/mast cells |
| CTLS | cytotoxicity/macrophage activation |
| NK | cytotoxicity/macrophage activation |
| ADCMC | NK cells |
| NKcell | antibody depdt cell med. cytotoxicity |
| FcRS | allow overlap btwn humoral and innate |
| induction | expansion |
| TH1 | IL-18 |
| TH2 | dev |
| RANTES | MIP-α/β bind CCR5 |
| TH1 | IFN-γ; tbet |
| TH1 | stat 4→IFN-γ ↑ th1 |
| IFN-γ | activates macrophages |
| activate-neutrophils | lymphotoxin & tnf |
| T-cell-amplification | ↑ B7 xprsn costims on MCH (B7) |
| Pro-B | CD43;CD19;CD10 |
| stemcell | CD43 |
| Pre-B | B220;CD43 |
| DC1 | myeliod IL-12+++ |
| DC2 | lymphoid Il-12+/- |
| early-IL-4 | DC1;IL-12;Th1 |
| persistent-IL-4 | DC2;Tha;Th2 |
