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Red Blood Cells

AB
AcanthocyteCell with irregular long projections
Acanthocytesporadically seen with severe liver disease or post-splenectomy; seen with rare disorder of abetalipoproteinemia
Acanthocyteseen with rare disorder of abetalipoproteinemia
AnisocytosisVariation in size of RBC's
BabesiosisSimilar to ring forms of malaria
Basophilic-stipplingSmall aggregates of RNA are seen as small blue dots in the RBC
Basophilic-stippling(fine)may be a feature of reticulocytes
Basophilic-stippling(coarse)toxic marrow damage; myelodysplasia & thalassemias
Tear-drop-cellprominent in myelofibrosis and myelophthisic conditions
Target cellseen with liver disease
Target cellintervening pallor due to ^redundancy of RBC membrane
StomatocyteCell with slit-like central pallor
Stomatocytenon-specific or an artefact
Stomatocytemany are seen with rare hereditary
Schistocytemicroangiopathic hemolytic anemias (DIC; TTP)
Schistocyteirregularly shaped seen with intravascular hemolysis
SchistocyteA variant called a "helmet cell" appears cut in half
Spherocytesuggests AI hemolytic anemia
SpherocyteSmall round dense cell without central pallor
hereditary-spherocytosisincreased osmotic fragility
SideroblastNon-nucleated RBC with stainable iron
ReticulocyteYoung RBC's with increased RNA content
Reticulocyteprecipitated by supravital staining for id & #
Polychromatophiliabluish tint to young RBC's w/high RNA content
PoikilocytosisVariation in shape of RBC's
Pappenheime-bodyMultiple
Pappenheime-bodyseen when spleen is absent and with iron overload
MicrocytosisCells with decreased MCV
Microcytosistypical of iron deficiency anemia and thalassemias
MacrocytosisCells with increased MCV
Macrocytosisovoid in megaloblastic anemias
Plasmodium infectionseen as "ring forms"; stippling and gametocytes
Hypochromiatypical of iron deficiency
HypochromiaCells with decreased MCH
Howell-Jolly-bodyseen when spleen is absent
Howell-Jolly-bodySmall
Heinz-bodyPcpttd Hgb seen only after supravital staining
Heinz-bodyperimembranous blue dot
Heinz-bodyseen with some hemoglobinopathies
macrocyteliver disease, alcoholism
liver disease, alcoholismstomatocyte
target celliron deficiency, hemoglobinopathy
pencil celliron deificinecy
microsphereocytesepticemia
fragmentsDIC, TPP, HUS
burnsfragments
microangiopathy, cardiac valvesRBC fragments
poikilocytemyelofibrosis
extramedullary hemopoiesispoikilocyte
basket celloxidant damage ex: G6PD def., unsatble hemoglobin
normoblastmarrow/DNA, RNA
reticulocytemarrow/blood/ RNA
mature RBCmarrow, blood / no RNA or DNA



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