| A | B |
|---|
| Precursor B-cell acute lymphoblastic leukemia/lymphoma | Diverse chromosomal translocations; t(12;21) involving CBFαand ETV6 most common rearrangement |
| Precursor B-cell acute lymphoblastic leukemia/lymphoma | Bone marrow precursor B-cell expressing TdT and lacking surface Ig |
| Precursor B-cell acute lymphoblastic leukemia/lymphoma | Predominantly children with symptoms relating to pancytopenia secondary to marrow involvement; aggressiv |
| Precursor T-cell acute lymphoblastic leukemia/lymphoma | Precursor T-cell (often of thymic origin) expressing TdT |
| Precursor T-cell acute lymphoblastic leukemia/lymphoma | Diverse chromosomal translocations, many involving T-cell receptor loci; rearrangements of TAL1 most common |
| Precursor T-cell acute lymphoblastic leukemia/lymphoma | Predominantly adolescent males with thymic masses; variable splenic, hepatic, and bone marrow involvement; aggressive |
| Burkitt lymphoma | Germinal center B-cell; CD10 expression usually seen |
| Burkitt lymphoma | Translocations involving c-myc and Ig loci; usually t(8;14), but also t(2;8) or t(8;22). African (endemic) cases latently infected with EBV |
| Burkitt lymphoma | Adolescents or young adults with jaw or extranodal abdominal masses; uncommonly presents as a "leukemia"; aggressive |
| Diffuse large B-cell lymphoma | Germinal center or postgerminal center B-cell |
| Diffuse large B-cell lymphoma | ∼30% BCL6; ∼10% t(14;18); subsetw/cREL amplification |
| Diffuse large B-cell lymphoma | All ages, but most common in adults; often appears as a single rapidly growing mass; 30% extranodal; aggressive |
| Extranodal marginal zone lymphoma | Postgerminal center memory B-cell |
| Extranodal marginal zone lymphoma | Trisomy 18, t(11;18), t(1;14); latter create MALT1-IAP2 and BCL10-IgH fusion genes, respectively |
| Extranodal marginal zone lymphoma | Arises at extranodal sites in adults with chronic inflammatory diseases; may remain localized; indolent |
| Follicular lymphoma | Germinal center B-cell; typically expresses CD10, BCL2, and BCL6 |
| Follicular lymphoma | t(14;18) involving the BCL2 gene |
| Follicular lymphoma | Older adults with generalized lymphadenopathy and marrow involvement; indolent |
| Hairy cell leukemia | Older males with pancytopenia and splenomegaly; indolent |
| Hairy cell leukemia | No specific chromosomal abnormality |
| Postgerminal center memory B-cell | Hairy cell leukemia |
| Mantle cell lymphoma | Naïve B-cell; expresses cyclin D1 and (usually) CD5 |
| Mantle cell lymphoma | t(11;14) involving BCL1 (cyclin D1) and IgH |
| Mantle cell lymphoma | Older males with disseminated disease; moderately aggressive |
| Multiple myeloma/ solitary plasmacytoma | Plasma cell derived from a postgerminal center B-cell |
| Multiple myeloma/ solitary plasmacytoma | Diverse rearrangements involving IgH |
| Multiple myeloma/ solitary plasmacytoma | Myeloma: older adults with lytic bone lesions, pathologic fractures, hypercalcemia, renal failure, and primary amyloidosis. Plasmacytoma: isolated plasma cell masses in bone or soft tissue (e.g., oropharynx) |
| Small lymphocytic lymphoma/chronic lymphocytic leukemia | Naïve B-cell or postgerminal center memory B-cell; expresses CD5 |
| Small lymphocytic lymphoma/chronic lymphocytic leukemia | Trisomy 12, deletions of 11q, 13q, and 17p |
| Small lymphocytic lymphoma/chronic lymphocytic leukemia | Older adults with bone marrow, lymph node, spleen and liver disease; most have peripheral blood involvement; autoimmune hemolysis and thrombocytopenia in a minority; indolent |
| Adult T-cell leukemia/ lymphoma | Helper T-cell expressing CD25 (IL-2 receptor) |
| Adult T-cell leukemia/ lymphoma | HTLV-1 provirus present in tumor cells |
| Adult T-cell leukemia/ lymphoma | Adults with cutaneous lesions, marrow involvement, and hypercalcemia; Japan, West Africa, and the Caribbean; aggressive |
| Anaplastic large cell lymphoma | Cytotoxic T-cell |
| Anaplastic large cell lymphoma | Rearrangements of ALK |
| Anaplastic large cell lymphoma | Children and young adults, usually with lymph node and soft tissue disease; aggressive |
| Extranodal NK/T cell lymphoma | Natural killer cell (common) or cytotoxic T-cell (rare) |
| Extranodal NK/T cell lymphoma | uniformly EBV associated |
| Extranodal NK/T cell lymphoma | Adults with destructive extranodal masses, most commonly sinonasal; often accompanied by hemophagocytic syndrome; aggressive |
| Mycosis fungoides/ Sézary syndrome | Helper T-cell |
| Mycosis fungoides/ Sézary syndrome | Adult patients with cutaneous patches, plaques, nodules, or generalized erythema; indolent |
| T-cell granular lymphocytic leukemia | Two types: (1) CD8+T-cell, (2) NK-cell |
| T-cell granular lymphocytic leukemia | Adult patients with splenomegaly, neutropenia, and anemia, sometimes, accompanied by autoimmune disease |
| Hodgkins, lymphocyte-depletion subtype | Germinal center or postgerminal center B-cell |
| Hodgkins, lymphocyte-depletion subtype | elderly and in HIV+individuals; moderately aggressive |
| Hodgkins, lymphocyte-depletion subtype | >70% EBV associated |
| Hodgkins, lymphocyte-predominance subtype | Germinal center B-cell |
| Hodgkins, lymphocyte-predominance subtype | Young to middle-aged males with cervical or axillary lymphadenophathy; indolent |
| Hodgkins, lymphocyte-rich subtype | Germinal center or postgerminal center B-cell |
| Hodgkins, lymphocyte-rich subtype | 40% EBV associated |
| Hodgkins, lymphocyte-rich subtype | More common in males, usually presents with lymphadenopathy; moderately aggressive |
| Hodgkins, mixed cellularity subtype | Postgerminal center memory B-cell |
| Hodgkins, mixed cellularity subtype | 70% EBV associated |
| Hodgkins, mixed cellularity subtype | More common in males, usually presents with lymphadenopathy; moderately aggressive |
| Hodgkins, nodular sclerosing subtype | Germinal center or postgerminal center B-cell |
| Hodgkins, nodular sclerosing subtype | rarely EBV associated |
| Hodgkins, nodular sclerosing subtype | Commonly presents as a mediastinal mass in young females; moderately aggressive |
