A | B |
Fibrinogen | factor I |
Prothrombin | factor II |
Tissue-factor | factor III |
CA+2 | factor IV |
FactorV | Proaccelerin;labilefactor;accelerator globulin(Ac-) |
FactorVII | Proconvertin;serum prothrombin conversion acceperator (SPCA);cothromboplastin |
FactorVIII | Antihemophilic factor A;antihemophilic globulin (AHG) |
FactorIX | Antihemophilic factor B; Christmas factor; plasma thromboplastin component (PTC) |
FactorX | Stuart-Prower factor |
FactorXI | Plasma thromboplastin antecedent (PTA) |
FactorXII | Hageman factor |
Factor XIII | fibrin stabilizing factor (FSF) fibrinoligase |
XII | binds to negatively charged surface |
XI | activated by factor XIIa |
IX | activated by factorXIa in presence of Ca +2 |
II | actvd on surface of actvd platelets by prothrombinase complex;also VIIA + tissue factor and Ca+2 |
Prothrombinase-complex | ( Ca +2 |
Gla-containing-zymogens | Factors II |
VIII | actvd by thrombin |
VIIIa | cofactor in actvtn of X by IXa |
V | actvd by thrombin |
Va | cofactor in actvtn of prothrombin by Xa |
Tissue-Factor-(III) | glycoprtn xprssd on surface of stim endo-t cl and monocyts |
III | cofactor for factor VIIa |
Factor-I | cleaved by thrombin to form fibrin clot |
Factor-XIII | actvtd by thrombin w/Ca+2;stblz clot by covalent crsslinking |
Protein-C | actvtdprtn Ca by thrombinbnd to thrombomodulin |
Protein-C+thrombomodulin | Degrades factors VIIIA and VA |
Protein-S | cofactor/protein C |
Protein-C-Protein-S | Contain Gla (γ-carboxyglutamate) |
Thrombomodulin | protein on the surface of endo-t cls; binds thrombinatvts protein C |
ADPase | AMP +Pi |
NO | inhibits platelet agg; adhsn by ^ cGMP |
Heparin-sulfate | anticoagulant;comb w/antithrombin to inhibit thrombin |
Prostacyclin | PGI2, inhibits platlet agg. By ^ cAMP |
Thrombomodulin | binds protein Cclvd by thrombinactvtd Protein C |
Protein-C+Protein-S | degrades factors Va and VIIIa |
Tissue-plasminogen-activator(t-PA) | actvts plasminogenplasmin |
Plasmin | digests fibrin |
Plasminogen-activator-imhibitor-1-(PAI-1) | opposes action of t-PA |