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Hemostasis and Thrombosis

AB
Fibrinogenfactor I
Prothrombinfactor II
Tissue-factorfactor III
CA+2factor IV
FactorVProaccelerin;labilefactor;accelerator globulin(Ac-)
FactorVIIProconvertin;serum prothrombin conversion acceperator (SPCA);cothromboplastin
FactorVIIIAntihemophilic factor A;antihemophilic globulin (AHG)
FactorIXAntihemophilic factor B; Christmas factor; plasma thromboplastin component (PTC)
FactorXStuart-Prower factor
FactorXIPlasma thromboplastin antecedent (PTA)
FactorXIIHageman factor
Factor XIIIfibrin stabilizing factor (FSF) fibrinoligase
XIIbinds to negatively charged surface
XIactivated by factor XIIa
IXactivated by factorXIa in presence of Ca +2
IIactvd on surface of actvd platelets by prothrombinase complex;also VIIA + tissue factor and Ca+2
Prothrombinase-complex( Ca +2
Gla-containing-zymogensFactors II
VIIIactvd by thrombin
VIIIacofactor in actvtn of X by IXa
Vactvd by thrombin
Vacofactor in actvtn of prothrombin by Xa
Tissue-Factor-(III)glycoprtn xprssd on surface of stim endo-t cl and monocyts
IIIcofactor for factor VIIa
Factor-Icleaved by thrombin to form fibrin clot
Factor-XIIIactvtd by thrombin w/Ca+2;stblz clot by covalent crsslinking
Protein-Cactvtdprtn Ca by thrombinbnd to thrombomodulin
Protein-C+thrombomodulinDegrades factors VIIIA and VA
Protein-Scofactor/protein C
Protein-C-Protein-SContain Gla (γ-carboxyglutamate)
Thrombomodulinprotein on the surface of endo-t cls; binds thrombinatvts protein C
ADPaseAMP +Pi
NOinhibits platelet agg; adhsn by ^ cGMP
Heparin-sulfateanticoagulant;comb w/antithrombin to inhibit thrombin
ProstacyclinPGI2, inhibits platlet agg. By ^ cAMP
Thrombomodulinbinds protein Cclvd by thrombinactvtd Protein C
Protein-C+Protein-Sdegrades factors Va and VIIIa
Tissue-plasminogen-activator(t-PA)actvts plasminogenplasmin
Plasmindigests fibrin
Plasminogen-activator-imhibitor-1-(PAI-1)opposes action of t-PA



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