| A | B |
| Roanoke Island | Founded by Sir Walter Raleigh |
| Jamestown | Founded by the Virginia Company of London |
| Plymouth | Founded by the Separatists |
| Separatists | Also known as the Pilgrims |
| Lost Colony | Nickname of Roanoke Island |
| John Smith | Leader of Jamestown |
| John Rolfe | Developed tobacco |
| No work, no eat | John Smith's rule |
| Croatoan | Only clue in Roanoke |
| Netherlands | Where the Pilgrims went first |
| Squanto | Helped the Pilgrims survive |
| Mayflower | Pilgrims' ship |
| 1585 | Year Roanoke was founded |
| 1607 | Year Jamestown was founded |
| Starving Time | Winter of 1609-1610 |
| Charter | Written permission to start a colony |
| Indentured Servant | Person who worked 5 to 7 years to pay off a debt |
| Cash Crop | Crop sold for money |
| 3 Days | Duration of the first Thanksgiving |
| 1619 | Year Africans and women came to Jamestown |