| A | B |
|---|
| Ceftriaxone, cefotaxime-3rd generation cephalosporins- | interfere with cell wall synthesis |
| Chloramphenicol- | inhibits microbial protein synthesis |
| Pen G | interferes with cell wall synthesis; good for gram negative |
| Rifampin | -inhibits RNA synthesis |
| N. Meningitidis | First choice: Penicillin |
| L. Monocytogenes | First choice:Ampicillin |
| H. Influenzae | First choice: Ceftriaxone, Cefotaxime |
| S. Pneumoniae | First choice: Penicillin G, Vancomycin |
| S. Pneumoniae | Second Choice: Chloramphenicol |
| H. Influenzae | Second Choice: Chloramphenicol |
| L. Monocytogenes | Second Choice: Trimethoprim sulfamethoxazole |
| N. Meningitidis | Second Choice: Ceftriaxone, Cefotaxime |
| used as prophylactic therapy for those in contact with cases of bacterial meningitis; kills carrier state | Rimfampin |
| 3rd generation cephalosporins (cefotaxime, ceftriaxone) are good alternative treatments due to their ability to penetrate the CNS | In cases of bacterial meningitis caused by N. Meningitidis |
| Eflornithine | Treats early and late stage of T. brucei gambiense only |
| Pentamidine | Early stage of T. brucei gambiense only |
| Suramin | Early stage of T. brucei rhodesiense and T. brucei gambiense |
| Melarsoprol | Usually given after administering suramin; Late stage of T. brucei rhodesiense and T. brucei gambiense |
| Nifurtimox | First choice for use with T. Cruzi |
| Benznidazole | Second choice for use with T. Cruzi |
| Late stage= | CNS phase of the disease |
| fewer side effects than melarsoprol | Eflornithine |
| Antiprotozoals-drugs for tx of p. jiroveci | Atovaquone, Trimethoprim-sulfamethoxazole, Pentamidine |
| Clindamycin plus pyrimethamine | second line regimin for p.jiroveci |
| Good for pts that can’t tolerate trimethoprim-sulfamethoxazole | Pentamidine |
| Primary antiprotozoal tx used to treat toxoplasmosis | Pyrimethamine-sulfadiazene |
| Azithromycin, Clarithromycin, Atovaquone, Dapsone | Any one of these drugs may be given in combination with pyrimethamine-sulfadiazene or trimethoprimsulfamethoxazole |
| Spiramycin | For acute toxo infection during pregnancy; concentrates in placenta |
| inhibits DHFA reductase of protozoa | Pyrimethamine-sulfadiazene |
| given with folinic acid to counteract toxicity | Pyrimethamine-sulfadiazene |
| Alternative to pyrimethamine-sulfadiazene | Clindamycin |
| Macrolides: clindamycin, azithromycin, clarithromycin | -inhibit bacterial protein synthesis by blocking 50S |
| Atovaquone | interferes with mitochondrial function |
| Dapsone | inhibits nucleic acid synthesis (inhibits dihydropteroate synthase and decreases use of p-aminobenzoic acid) |
| Tri-sulf | inhibts DHFAR-bacteriocidal |
| inhibits RNA synthesis by binding to bacterial RNA-pol- bacteriocidal | Rifampin |
| Clarithromycin | has good activity against Leprosy |
| Ethionamide | Given as an inactive pro-drug that ultimately inhibits cell wall synthesis-can sub for clofazimine-often used as a 2ndary agent |
| Drugs used to treat leprosy | Dapsone,Rifampin,Clofazimine,Clarithromycin,Ethionamide |
| Dapsone | bacteriostatic |
| Viral encephalitis | acyclovir |
| Rabies | prophylactic treatment postexposure |
| Rabies | hyperimmune globulin, human diploid cell vaccine |
