| A | B |
|---|
| colchicine indications | Acute Gout |
| colchicine MOA | inhibits migration and phagocytic actions of granulocytesand PMN elaboration of inflammatory glycoprotein |
| colchicine side effects | nausea, vomiting, diarrhea, abdominal pain ; affects rapidly proliferating epithelial cells |
| allopurinol MOA | parent drug and metabolite alloxanthine inhibit xanthine oxidase, ¯ uric acid synthesis |
| inhibits metabolism of azathioprine, 6-mercaptopurine | allopurinol drug interaction: |
| tx for chronic gout with impaired renal function | allopurinol |
| probenecid MOA | uricosuric agent, inhibits uric acid renal tubular reabsorption |
| probenecid drug interactions | multiple due to blocking renal secretion |
| sulfinpyrazone indications | chronic gout tx with no anti-inflammatory or analgesic properties |
| probenecid | developed to inhibit renal tubular secretion of penicillin |
| colchicine side effects | interferes with mitotic spindle function |
