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Toxicology I

Includes:
I. Introduction
II. Poison Control Centers (PCC)
III. Information Sources
IV. Supportive care

AB
TQ! may be poisonous at a given dose and route of admin.any chemical
agencies that are assd with poison controlAAPCC and TESS
TQ? The 3 incidences that account for 30% of poisonings in child <6cosmetics, cleaning subst., plants
the most important reason for poisonings in childrendosing errors
reason for dosing errorshousehold spoons come in different sizes
TQ? #1 place for poisonings to occur.home
poison control center staffpharmacists, nurses, and director (usu MD)
TQ! most imp. question when analyzing a poisoning situationname and phone number
TQ! second most imp. quest. in poisoning situation.How is the patient doing? breathing? coughing? etc.
when route of admin. is oral, concerned with......lipid solubility, nonionized form, food, first pass, bezoars
make oral poisons more readily absorbablelipid solubility and non-ionized form
reason food is bad with oral poisoningsdelay abs.->inc. contact time in stomach -> more absorbed
mass in stomach that doesn't disolve easilybezoar
Problem with inhalation poisoningsinc. onset bcs rich blood supply and lg. surface area.
problem with dermal poisoningsorgans most readily avail. to ALL substances, lipid solubility, wounds
route of admin of poison with most rapid onset -> mult. organ failureIV
which is more rapid onset: subQ or IMsubQ
the least rapid onsettopical
which has the most rapid onset: intradermal or IMIM
least rapid onset: oral or IMoral
if know * and *, can determine if the symptoms are consistant w/ amt. ingested and time since exp.onset and duration of action
clinical manifestation of poisoning that -> immed. medical attention.CV and respiratory involvement
some tx modalities are * when certain S/S are present(ie: coma)contraindicated
helps determine the toxicity of substance to pt. and dosing of antidoteage and wt.
may complicate tx and influence recommendationPMH and prior therapy (home remedies or tx)
TQ! chemicals that are metabolized to more toxic substancesacetaminophen and methanol
database in Micromedix that lists s/s of durgs, avail at PCCpoisindex
what do you treat first with a poisoning?the patient(airway, CV, CNS) not the poison


Suzanne M. Clous

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