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NSAIDS

AB
MOA ReviewCox1- prostaglandin synthase in protective, cox 2- prostaglandin is induced following stimulation by inflammatory mediators
newer nsaidsdeveloped to target cox2, goal to decrease inhibition of physiologically important prostaglandins therefore reducing side effects
adverse effectsGI, vomiting, ulcerations, death treatment: h2 blockers,
renal effectsprotective role, dehydration and shock, anesthesia renal disease increase risk
idiosyncraticcannot predict, not due to dosage
intrinsicpredictable, dose related, aspirin, acetaminophen
aspirinAAA properties, decreases platelet aggregation, no withdrawl time in food animals,
adult aspirin325mg
baby aspirin65mg
Diproyneantipyretic, analgesic
Flunixin Megluminebaniname, only in horses, aaa action
Meloxicamappoved for dogs and cats, SID less than 10lbs administer on food
Tepoxalininstantly dissolves, hold mouth shut for 10 seconds
Adequanhorses, IM use
Arquellabeled in horses, used for acute and chronic inflammatory disease, do not use in pregnant mares


Social Studies Grade 4
Potters Road Elementary

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