| A | B |
|---|
| tricyclic drug interactions | antihistamines, ethanol (additive sedation) |
| causes inc in TCA concentration | cimetadine, ethanol, SSRI |
| drugs that have concentration inc with TCA | warfarin, phenytoin |
| causes dec in TCA concentration | anticonvulsants (phenobarb, carbamazepine), chronic ethanol use |
| drug that causes inhibition of cyP450 -> arrythmias with cisapride | nefazadome (heterocyclic) |
| drugs whose concentrations are inc by heterocyclics | digoxin, haloperidol |
| drug class that causes additive sedation with other meds | heterocyclics |
| drug class that can not be taken with tyrosine containing foods | MAOI |
| MAOI and tyrosine containing foods lead to * | Hypertensive crisis: stiff neck, headache, sweating, big inc in BP |
| TX for hypertensive crisis in MAOI/tyrosine hypertensive rxn | nifedipine, phentolamine |
| most common adverse of MAOI (and which drug commonly assd) | hypotension; phenelzyne |
| TX for OD of MAOI | sedation, alpha blockers |
| drug class assd with seratonin syndrome | SSRI |
| S/S of seratonin syndrome | hyperthermia, muscle rigidity, myoclonus, mental status changes, change in vitals |
| drugs that inc s/s of seratonin syndrome | ultram, MAOI |
| DI with fluvoxamine (why?) | terfenadine, aztemizole, cisapride -> arrythmias; inhib cyP450 |
| DI with paroxetine, fluoxetine (why?) | metab. inhib: desipramine, nortripyline, flecanide; caused by inhib. of cyP2D6 |
| meds used first in antidepressant therapy | TCA, SSRI |
| outpatient antidep. tx | start with small dose, slow increases |
| inpatient antidep. tx | start with high doses; change ev. 2-3 days |
| meds that need to be given early in the day | MAOI, SSRI |
| if first event and pt. responds well | withdraw med after several mo.;if no relapse, start at next episode |
| if pt has frequent relapses, or become more severe | use maintenance dose, usu a full dose |
