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Chapter 15 by Lacey Hodges

The Chromosomal Basis of Inheritance

AB
chromosomal theory of inheritanceThe theory that chromosomes are linear sequences of genes.
wild typeThe normal phenotype for a character (the most common in natural populations).
sex-linked genesGenes located on a sex chromosome.
linked genesGenes located on the same chromosome that tend to be inherited as a unit.
genetic recombinationThe general term for the production of offspring with new combinations of traits inherited from two parents.
parental typesThe phenotypes of the P generation in punnett square crosses.
recombinantsOffspring with new combinations.
genetic mapAn ordered list of the genetic loci along a particular chromosome.
linkage mapA genetic map based of recombination frequencies.
map unitEqual to a 1% recombination frequency.
cytological mapsLocate genes with respect to chromosomal features.
Duchenne muscular dystrophyA sex-linked disorder that causes the progressive weakening of muscles and loss of coordination.
hemophiliaA sex-linked recessive trait defined by the absence of one or more of the proteins required for blood clotting.
Barr bodyThe inactive X in each cell of a female condenses into a compact object called a..
nondisjunctionA mishap where chromosomes do not separate properly and one gamete receives two of the same type of chromosome while the other gamete receives none.
aneuploidyWhen an aberrant gamete unites with a normal one during fertilization, producing an offspring with an abnormal chromosome number.
trisomicWhen a cell has a triplicate of one chromosome (2n+1).
monosomicWhen a cell is missing a chromosome (2n-1).
polyploidyAn alteration where an organism has more than two complete chromosome sets.
deletionOccurs when a chromosomal fragment lacking a centromere is lost during cell division.
duplicationOccurs when an extra fragment is attached as a segment to a sister chromatid.
inversionOccurs when a chromosomal fragment reattaches to the original chromosome, but in the reverse orientation.
translocationOccurs when a fragment joins a nonhomologous chromosome.
Down syndromeAn aneuploid condition that is usually the result of an extra chromosome 21.
genomic imprintingA process where a gene on one chromosome is silenced, while its allele on the homologous chromosome is left to be expressed.
fragile X syndromeA disorder named after the appearance of the chromosome itself: the tip of it hangs on the the rest of the chromosome by a thin thread of DNA. This causes the most common form of mental retardation.



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