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Chapter 12 by Rodger Ewy

The Cell Cycle

AB
cell divisionthe reproduction of cells
cell cyclethe life of a cell from its origin until it's division
genomeall of the genetic information in a cell
chromosomesthe packages of DNA molecules
somatic cellsbody cells, that are not reproductive cells
gametesreproductive cells (sperm, and egg cells)
chromatinthe DNA-protein complex that maintains the structure of the chromosome and help control the activity of the genes
sister chromatidstwo chromatids containing identical copies of the chromosome's DNA molecule
centromerea narrow "waist" region on the chromosome
mitosisthe division of the nucleus
cytokinesisthe division of the cytoplasm
meiosisa variation of cell division that produces gametes
M phasea part of the cell cycle that contains both mitosis and cytokinesis
interphasecell grows and copies chromosomes in preparation for cell division
G1 phasecell grows during this part of interphase
S phasechromosomes are duplicated during this phase
G2 phasecontinues to grow and complete preparations for cell division
prophasenucleoli disappear and chromatin fibers condense into chromosomes
prometaphasenuclear envelope fragments
metaphasecentrosomes are at opposite poles of the cell and chromosomes line up in the center of the cell
anaphasepaired centromeres of each chromosome separate
telophasedaughter nuclei form at the two poles of the cell
asters ("stars")shape that the microtubules extend from the centrosomes during g2 phase
kinetochorea specialized structure of a chromosome located at the centromere region
metaphase platean imaginary plane that is equidistant between the spindle's two poles during metaphase
mitotic spindlestructure that consists of fibers made of microtubules and associated proteins
centrosomea non-membranous organelle that functions throughout the cell clycle to organize the cell's microtubules
cleavagea process by which cytokinesis occurs
cleavage furrowa shallow groove in the cell surface near the old metaphase plate, it is deepened as the parent cell is pinched in two
cell plateonly in plant cells, and is a wall erected between the two daughter cells
binary fissionThe way that prokaryotes reproduce, means literally " division in half"
origin of replicationthe copies of the first replicated region
cell cycle control systema cyclically operating set of molecules in teh cell that both triggers and coordinates key events in the cell cycle
checkpointa critical control point in the cell cycle where sop and go-ahead signals can regulate the cycle
G0 phaseif a cell does not receive a go-ahead signal at the g1 phase it exits the cell cycle and enters this phase
cyclina protein that gets its name from its cyclically fluctuation concentration in the cell
cyclin-dependent kinases (Cdks)kinases that drive the cell cycle are always there in a growing cell but must be activated by their cyclin partner
MPFthe fluctuating activity of the cyclin-Cdk complex that was discovered first
growth factora protein released by certain body cells that stimulates other cells to divide.
density dependent inhibitiona phenomenon in which crowded cells stop dividing
anchorage dependenceto divide the cell must be attached to a substratum, such as the insid of a culture jar or the extracellular matrix of a tissue
transformationthe process that converts a normal cell to a cancer cell
tumora mass of abnormal cells within otherwise normal tissue
benign tumorabnormal cells remain at the original site
malignant tumorabnormal cells that become invasive enough to impair the functions of one or more organs
metastasisThe spread of cancer cells to locations distant from their original site



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