| A | B |
|---|
| aspirin | example of inhibiting cox 1 & 2 |
| effects of COX 2 | pain and inflammation |
| effects of COX 1 | protect GI mucosa, help with clotting, promotes renal function |
| aspirin is extensively bound to this | albumin |
| misoprotstol | drug which helps prevent aspirin from destory gastic mucosa |
| how aspirin affects kidneys | decreases GFR & renal blood flow |
| signs of salicylism | tinnitus, sweating, headache & dizzinesss, acid / base disturbances |
| irreversible inhibitor of cox | aspirin |
| contraindications to taking nsaids | PUD, bleeding disorders, i.e vitamin K deficiency, pregnancy, children |
| meds interacting with aspirin | warfarin, heparin, glucorticoids, alcohol, ibuprofen |
| inhibitiion of COX-1 causes | gastric erosion, bleeding, renal impairment |
| inhibition of COX-2 causes | suppression of inflammation, alleviation of pain, reduction of fever, protection against colorectal cancer |
| example of first generation nsaid | diclofenac |
| example of second generation nsaid | celecoxib |
| side effects of celecoxib | dyspepsia, abd. pain, renal toxicity |
| contraindication to celecoxib | sulfa allergy |
| acetaminophen mechanism of action | inhibits prostaglandin synthesis in CNS |
| adverse effecrts of acetaminophen | hepatic toxicity |
| acute toxicity of acetaminophen symtpoms | nausea, vomiting, diarrhea, sweating |
| treatment for acute acetaminophen toxcity | acetylcysteine (Mucomyst) |
| examples of salicylates | aspirin, magnesium salicylate, sodium salicylate |
| examles of propionic acid derivates | ketoprofen, flubiprofen, ketoproen, aproxen |
| example of second generation nsaid | celecoxib |
| examples of "other" nsaids | diclofenac, indomethacin, piroxicam |
| example of salicylate | Arthropan |
| ibuprofen can cause | hypoglycemic |
| this nsaid has a longer half life | piroxicam |
