| A | B |
|---|
| low doses of glucocorticoids used to treat | endocrine disorders |
| hi doses of glucocorticiods used ot treat | suppress immune responses, certain cancers &inflammatory disorders |
| different GCT due to | time, course of action & side effects |
| metabolic effects at low doses | elevate glucose, stimulate lipolysis, divert amino acid to produce glucose |
| cv effects of GCT | affect capillary permeability, affect # of leukocytes & # of rbc's |
| low dose GCT | can cause retentionof sodium & water |
| low dose GCT in infants | can hasten resp. sytem maturity |
| high dose GCT efects on immune system | immunosuppresant and anti-inflammatory effect |
| therapeutic uses of high dose GCT | Rheum. arthritis, SLE, IBD, asthma, neoplasms, derm disorders, transplants, prevention RDS |
| GC secretion through: | hypothalamus, to pituitary to adrenal cortex |
| abrupt discontinuation of GC can lead to | adrenal crisis |
| adverse effects of GC | osteoporosis, infection, glucose inteolerance, myopathy, fluid & electrolyte disturbances, growth retardation, mood changesm, cataracts, glaucoma, pud, cushing's syndrome |
| effects of GC on electrolyes | loss of potassium |
| drug interactions of GC | digoxin, nsaids, insulin, diuretics |
| GC with digoxin may cause | dig toxicity secondary to hypokalemia |
| GC with nsaids may cause | PUD |
| GC with diuretics | hypokalemia |
| diabetics may require | more insulin on GC's |
| GC with vaccines | decrease antibody response |
| reduce the suppression of adrenal glands | administer gc's every other day |
| in times of stress, pt's on GC's need | higher doses of GC's |
| to avoid adrenal crisis need to | taper off GC's/taper dose |
| take GC's | with meals |
| avoid this while taking GC's | alcohol |
| if miss dose | don't double up |
| dietary recommndations on gc's | limit sodium, increase potassium |
| recommend that diabetics on gc's | monitor glucose levels |
| avoid this vaccine during gc's | oral polio vaccine |
| long acting gc | betamethasone, dexamethasone |
| intermediate acting gc | prednisone, triamciniolone |
| short acting gc | cortisone, hydrocortisone |
| high mineralocorticoid | cortisone |
| moderate mineralcorticoid | prednisone |
| low mineralcorticoid | dexamethasone |
| consider these in patients on GC's | vit D & calcium |
