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Karen Unit 11-13 test review 10/30/10

AB
differences between 1st & 2nd generation2nd generation non sedating & doesn't cross bbb
Uses for antihistaminesmild allergy, anaphylaxis, motion sickeness, insomnia, common cold , vertigo, parkinson's, antiemetics
Contraindications to antihistaminesasthma, urinary retention, open angle glaucoma, htn, BPH, pregnancy
contraindications to 2nd generationemycin, clarithromycin, azoles due to risk of fatal dysrhymias
signs of toxicitiy of antihistaminesfever, flushing dry mouth, confusino, ildated pupils, tachycardia, urinary retention
precautions with asaPUD, bleeding disorders, pregnancy, hypersensitivity, children, liver, kidney, heart failure
precautions with tylenolliver disease, alcohol use
tx tylenol toxicity withMucomist (acetylcystine)
precautions with cox2sulfa allergy, 3rd trimester of pregnancy (due to premature closure of ductus arteriosus in fetus), PUD, heart problems
effects of overdose of ASAincreased resp. depression, acidosis, hyperthermia, sweating, dehydration, stupor, coma, death
effects of overdose of tylenolliver failure/hepatotoxicity; may increase bleeding risk with coumadin; nausea, vomiting, diarrhea, sweating, hepatic coma, death
effects of toxicity cox2 inhibitorsPUD, cardiovascular effects, renal failure
low doses of glucocorticoids used to txendocrine disorders
high doses used to txcause immune suppression (ie transplant), rheumatological disorder, SLE, IBD, misc. inflammatory disorders, allergic conditions, asthma, dermatologic disorders, neoplasms, ALL, prevention of RDS in preterm infants
adverse effectsadrenal insufficiency, osteoporosis, infection, glucose intolerance, fluid/electrolyte disturbance, growth retardation, psych disturbance, PUD, Cushing's syndrome
glucocorticoid drug/drug intereactionsdigoxin, diuretics, nsaids, insulin/oral antidiabetic agents, vaccines
contraindications/precautions to glucocorticoidscontraindications: systemic fungal infections;pediatric patients, diabetics, htn, chf, renal impairment, PUD


Dr. Hyla Harvey
Marshall University Joan C. Edwards School of Medicine
Hurricane, WV

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