| A | B |
|---|
| how diuretics work | increase urinary output; blockade of sdium & chloride reabsoprtion, increasing water in collecting tubule |
| side effects of loop/thiazide | dehdyration, hypotension, hypokalemia, hyponatremia, hypochloremia, hypocalcemia, hyperuricemia, hyperlipidemia, ototoxicity (loop only) |
| side effets of potssium sparing | hyperkalemia, endocrine effects |
| side effects of osmotic | n, v, HA, edema |
| drug/drug int. loop/thiazides | anticoagulants/displaces warfarin; digoxin, ototoxic drugs; lithium, antihtn ages, nsaids |
| drug/drug potssium sparing | potassium supplements, ACE I, |
| do this to review diuretics | Look at the summary page Hyla wrote & put in your book! |
| most effective diuretic | loop |
| how ACE I work | inhibit angiotensin converting enzyme resulting in vasodilation and decreased blood volume |
| side effects ACE I | 1st dose htn, cough, hyperkalemia, renal failure, fetal injury, angioedema |
| pregnancy ACE I | dc before 2nd trimester |
| drug /drug ACEI | diuretics, antihtn drugs, drugs that raise potssium levels, lithium, nsaid's |
| uses of ACE I | htn, chf, after MI reduces mortality, diabetic nephropathy, proteinuria in diabetes |
| how ARBS work | blocks angiotensin II at adrenals, blood vessels & all other tissues |
| side effects of ARBS | renal failure, fetal harm, angioedema |
| pregnancy ARBS | fetal harm, like ACE I's |
| uses of ARBs | HTN, CHF, diabetic nephropathy, post mi, migraines |
| drug/drug ARBs | almost none |
| aldosterone antagonists how work | block aldosterone receptors, promoting renal excretion of sodium & water |
| uses of aldosterone antagonists | htn & CHF |
| side effects | hyperkalemia, impaired renal funcction, endocrinololgical abnormalities |
| drug/drug aa's | inhibitors of cyp3A4; can increase levels of emycin, verapamil, fluconazole |
| review calcium channel blockers by | looking at the paper Hyla made and put in the book!!! |
| dilation of arterioles affects | decreased afterload |
| dilation of veins affects | decreased preload |
| side effects vasodilators | orthostatic hypotension, reflex tachcardia, expansion of blood volume secondary to prolonged vasodilation |
| compare venous & arteriolar vasodilation | look at chart on vasodilation by Hyla in the book |
| can cause SLE type symptoms | hydralazine |
| can cause cyanide poisoning | nitroprusside |
| compare hydralazine & nitroprusside | look at the hydralazine & nitroprusside chart Hyla made in the book! |
