| A | B |
| Christopher Columbus | and Italian explorer who died believing he had reached Asia |
| King John II | Portuguese King who did not help Columbus's voyages |
| King Ferdinand and Queen Isabella | Spanish King and Queen who were convinced to support Columbus |
| Amerigo Vespucci | The first person to call the Americas a "new world" |
| Moctezuma | Ruler of the Aztecs |
| Hernando Cortes | Conquered the Aztec Empire |
| Dona Marina | Aztec woman who was an ally of Cortes |
| Francisco Pizarro | Conquered the Incan Empire and Incan Ruler |
| Atahualpa | Incan Ruler |
| Hernando de Soto | Went on an expedition in search of gold and other riches |
| Esteban | Enslaved African sailor who searched for Cibola |
| Alvar Nunez Cabeza de Vaca | Explored present day Texas in search of Cibola |
| Francisco Vasquez de Coronado | Sent by the governor of New Spain to find Cibola |
| Bartolome de Las Casas | Spoke out against the mistreatment of native peoples |
| San Salvador Island in the Bahamas | First place Columbus arrived on his first voyage |
| Tenochtitlan | Capital City of the Aztecs |
| New Spain | Colony established by Spain in 1535 |
| Mexico City | Capital of New Spain |
| Cuzco | Incan Capital City |
| Lima | New capital founded by Pizarro in the colony of Peru |
| Hispaniola | The first enslaved Africans were brought here |
| Cibola | The city that did not exist |