| A | B |
|---|
| aminoglycocides side effect\s | renal & ototoxic side effects |
| major route of administration for aminoglycs | IV (or IM) NOT PO |
| aminoglycs are bacteriocidal or static? | bacteriocidal |
| aminogycs work by | produces wrong aa's & causes cell death |
| aminoglycs normal renal half life | 2-3 hours |
| if renal failure, what is done with aminoglycs? | decrease the dosage frequency or decraese the dosage |
| aminoglycs can be monitored by | serum levels (different in different people) |
| monitor peak levels of aminoglycs to | achieve bacteriocidal effects |
| monitor trough level so aminoglycs | are less toxics |
| ideal peak level | no more than 12 |
| ideal trough level | not more than 2 |
| aminoglycs interact with | penicillins (can inactivate the drug), ototoxic Or nephrotoxic drugs |
| examples of aminoglycs | gentamycin |
| gentamycin used for | gram negatives (klebsiella, ecoli, pseudomonas, serratia) |
| optimum dosage for gent. | once daily |
| amikacyin is useful because it is | most broad spectrum of aminoglycs |
| neomycin | used topically (not used parenterally) |
| streptomycin | used with otehr meds in tb |
| paramimycin used for | intestinal amebiosis & tapeworm infections |
| nursing stuff for aminoglycs | monitor hearing , make sure serum levels performed, check I/O's |
| aminglycs cause what kind of damage to inner senosry cells of inner ear | irreversible damage |
| aminoglycocides are broad or narrow spectrum? | narrow spectrum |
| nephrotoxicity of aminoglycs related to | total cumulative dose |
| ototoxicity of aminioglycs related to | trough levels |
| aminoglycs bacterial resistance caused by | enzyme productive that inactivates them |
| early symptom of impending vestibular damage | headache |
| avoid use wtih aminoglycs due to possible nephrotoxicity | nsaid's |
| which aminoglyc is least susceptible to inactivation by enzyme | amikacin |
| which aminoglyc is the most nephro & oto toxic | neomycin |
| when to get trough levels | right before the next dose |
| symptom of impending cochlear damange | ringing in the ears |
