| A | B |
|---|
| use of antipsycotics | used to decrease agitation & psychtic symtpoms |
| how antipsychotics work | blocking postsynaptic dopamine receptors |
| site of action of antipsyichotics | basal ganglia, hypothalmus, medulla |
| low potency | requires higher doses, more anticholinergic effects |
| examples of low potency | chloropromazine, thioridiazine (thorazine, mellaril) |
| high potency | more likeliy to cause extrapyramidal symptoms |
| ex. high potency | prolixin, stelazine, navane, haldol |
| moderate potency | nothng to say about these |
| ex of moderate potency | trilathon, loxatane, moban |
| dangerous side effect of agranulocytosis & decreased seizure threshold | clozapine |
| meds w/weaker dop receptor antagonuists | more potent antagonists of serotonin receptors |
| common side effects of atyp8cals | wt. gain, hyperglycemia, elevated chol & triglycerides |
| examples of atypicals | clozaril, zyprexa, abioify, geodon, seroquel, invega |
| FDA approved for peds/adolescents | risperidoen (Risperdal) |
| contraindcations to antipsycotics | CNS depression, blold dysrasia, renal/cardiac insufficiency, cauition in elderly/kids |
| effect of beta blockers with antipsychotics | severe hypotension |
| tegretol or cig. smoking with antipsychotics | decreases antipsychiotic concentrations |
| exrapyramidal side effects | akinesia, akathesia, dystonia, etc. |
| pseudoparkinsonism | drooling, rigidity, shuffling gate, tremor |
| akinesia | muscular weakness |
| akasthesia | restlessness |
| dystonuia | involuntary movements of face, arms, neck |
| occular gyrocrisis | uncontrollable rolling back of eyes |
| eps side effects most common in | high potentcy antipsychotic agents |
| ex of meds for eps symtpoms | cogentin, artane, symmetrol |
| tardive dyskinesia | tongue movements, facial movements, potentually irreversible |
| neuroleptic malignant syndrome | abnl. vital signs, muscle ridigity, stupor, coma, more common intypical antipsychotics |
| less common side effects | sedation, nausea, gynecomastia, rashes, sun sensitivity |
| avoid this with antipsychotics | alcohol |
| clozaril | dangerous atypical need to monitor labs weekly |
