| A | B |
| House of Burgesses | the first colonial lawmaking assembly |
| Separatist | a person who wanted to separate from the Church of England |
| Northwest Passage | nonexistent water route explorers searched for that would flow through North America connecting the Atlantic and Pacific Oceans |
| indentured servant | person who agreed to work for a certain amount of time, unpaid, in exchange for a paid voyage to the New World |
| persecution | unjust treatment because of one's beliefs, ethnic origin, or race |
| cash crop | a crop grown to be sold for profit |
| Pilgrim | a person who travels to a new place for religious reasons |
| dissenter | a person whose ideas differ from those of his or her leaders |
| debtor | someone who owes money |
| Jamestown | the first permanent English settlement in the New World |
| Roanoke | the "lost colony" that was England's first attempt to colonize America |
| John Smith | leader of the Jamestown colony through its hardest times |
| Sir Walter Raleigh | organizer of the attempts to colonize Roanoke |
| Pocahontas | daughter of Chief Powhatan |
| Chief Powhatan | leader of the Powhatan people |
| John White | leader of the second attempt to colonize Roanoke |