| A | B |
| Columbian Exchange | the name used to describe the people, plants, and animals that crossed the ocean after Columbus's voyage |
| privateer | the captain of an armed, privately-owned ship |
| navigation | the science of plotting and controlling the course of a ship |
| invasion | the use of force to conquer |
| slavery | a cruel system in which people worked without pay or freedom |
| settlement | a community of people in a new region |
| epidemic | the spread of disease among many people |
| immunity | a resistance to a disease |
| armada | the Spanish word for "fleet" |
| circumnavigate | to sail around the world |
| conquistador | the Spanish word for "conqueror" |
| Northwest Passage | the name of the waterway that England and France believed existed to the East |
| plantation | a large farm built by the French to meet the sugar demands of the 1500s |
| legend | a story handed down from earlier times |
| ambush | to attack someone by surprise |
| compass | an invention that made travel by sea easier |
| Magellan | the first explorer to have his expedition circumnavigate the globe |
| mining | one of the kinds of work that slaves were forced to do in the Americas |
| Cortes | the explorer who defeated the Aztecs |
| Pizarro | the explorer who defeated the Incan Empire |
| Prince Henry | the prince of Portugal who was first to sail around Cape Bojador, Africa |
| Columbus | the explorer who first reached the Americas for European exploration |
| Spanish Armada | the event that led England and France to challenge the power of Spain |
| sugar | the crop harvested by slaves on French plantations during the 1500s |
| The Victoria | Magellan's ship that was first to circumnavigate the globe |