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Cell Bio 4100 Aerobic Respiration Part 2

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Mitochondrion, cytoplasmic membrane ofAerobic Respiration
Mitochondrion Outer membrane:50/50 lipid/protein and Mitochonrial porin
Mitochondrion Intermembrane spaceContinuous with cytosol
Mitochondrion Inner membrane75% protein, highly impermeable, Cristae, and Studded with ATP synthase
GlycolysisIs a catabolic process; Occurs in the cytosol; One molecule of glucose is partially oxidized to smaller molecules to generate ATP and reduced NADH + H+
1 Glucose yields:2 pyruvates, 2 ATPs, 2 NADH + 2H+
Allosteric mechanisms control enzymaticturn glycolysis “up” or “down”
Hexokinase inhibitedby glucose 6-phosphate
Pyruvate kinase inhibitedby ATP
Phosphofructokinase-1 regulated byATP/AMP, fructose 2,6-bisphosphate
Phosphofructokinase-1 SubstratesATP (ADP + Pi) and Fructose 6-phosphate


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