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Cell Bio 4100 Aerobic Respiration Part 3

AB
Citric Acid Cycle: Pyruvate + CoASH + NAD+ →AcetylCoA + CO2 + NADH (transition step)
Citric Acid Cycle: AcetylCoA + 2 H2O + FAD + 3 NAD+→2 CO2 + FADH2 + 3 NADH + GTP
Fatty Acid converted tofatty acyl CoA in cytosol
Fatty acid covalently transferred tocarnitine; transported across inner mitochondrial membrane; reattached to CoASH
Carbons from fatty acyl CoA are transferredin twos to acetyl CoA
For every two carbons transferred to CoASH:FADH2 and NADH
High energy e- stored in NADH and FADH2 are passed down toa series of molecular complexes by alternating reduction/oxidation reactions
Reducing Power At the End of Citric Acid Cycle2 NADH from glycolysis
“Prosthetic Groups”Capable of being reduced and oxidized and Electron carriers
Proton Motive ForceCombination of ΔpH and Δ charge across membrane and Drives synthesis of ATP in ATP synthase and Chemiosmotic hypothesis
ATP SynthaseF0 and F1 domains, F0 domain embedded in inner mitochondrial membrane, and F1 domain protrudes from membrane into matrix
Complex IV Cytochrome c Oxidasee- transferred from reduced cytochrome c
Complex I NADH-CoQ Reductase2 e- transferred from NADH
Complex II Succinate-CoQ Reductase2 e- transferred from FADH2
Complex III CoQH2-Cytochrome c Reductase2 e- transferred from CoQH2 to cytochrome c


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