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Cell Bio 4100 Cytoskeleton

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CytoskeletonPolymer network of filamentous, proteinaceous structures
Cytoskeleton FunctionsLend architecture and support, Provide framework, Provide machinery for movement of cell, Play important role in cell division
Cytoskeletal Elements areDynamic
Cytoskeletal Elements are capable ofcollapse and reorganization
Actin PolymerizationNucleation phase, Elongation phase, Steady state phase
In Microfiliament Growth Rate of addition of G-actin-ATP depends onconcentration of free monomers
TreadmillingPowered by hydrolysis of ATP
Microfilament Cross-linking proteinsFimbrin, α-actinin, Spectrin, filamin
Adaptor ProteinsAnchor filaments to cell membrane
Myosin Motor ProteinsAll myosins convert ATP hydrolysis into work
Most myosins move towardplus (+) end of microfiliament
Myosin VI moves towardminus (-) end of microfiliament
SarcomereUnit of Contractility
I bandthin filaments
A bandthick filaments
Muscles move byshortening


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