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History and Basic Concepts (of Developmental Biology)

A review of vocabulary found in Chapter 1 of Introduction to Development by Wolpert, et al (Oxford University Press - USA).

AB
allometric growthas body size increases, relative proportions of body parts changes
animal poleend of egg that roughly marks the site of the future mouth
antero-posterior axisline drawn from head to tail
apoptosisprogrammed cell death
asymmetric divisionscell division that partitions cytoplasmic determinants unequally
axesimaginary lines that lay out the basic directions in the body
blastocoelfluid-filled cavity in early embryo
blastoporesite of invagination of cells during gastrulation
blastulaembryo that is a ball or disk of cells with an internal fluid filled cavity
body plananatomical arrangement of organism
cell differentiationrestriction of cell fate/potential during development
cell lineageall of the cells that give rise to any individual cell in an organism
cell signallingthe way that intercellular information is generated and perceived
cleavagecell division
competenceability to respond to a signal
cytoplasmic localizationpresence of a molecule in the cytoplasm of a cell
determinantsmaterials that generate morphogenic or positional signals
diffusionmovement of molecules from an area of high concentration to low concentration
diploidhaving two copies of each type of chromosome
direct contactimpacting immediately neighboring cells
dorso-ventral axisline drawn from back to front
ectodermgerm layer giving rise to skin, nervous system and neural crest
embryodevelopmental stage from 2-cell to fetal stage
endodermgerm layer that gives rise to many cell types of abdominal organs
fatecell type an embryonic cell will give rise to if not disturbed
gap junctionopen channel between cells in which each cell donates half of the channel
gastrulationstage of development generating trilaminar embryo
genotypeexact genetic makeup of an organism
germ layersthree basic sheets of cells generated during gastrulation
gradientconcentration pattern of a material in a system
haploidgenome composed of one of each type of chromosome
inductionproduction of morphogen by one tissue that changes developmental property of responding tissue
lateral inhibitionhormone made by one cell prevents formation of structure in the vicinity of that cell
meiosisnuclear division that generates haploid reproductive cells in sexual reproduction
mesodermgerm layer that gives rise to connective tissue in the embryo
mitosisnuclear division that results in exact duplicates of parental cells
morphogenhormone produced in an embryo that changes developmental property of target cell
mRNARNA used as a template to make protein
neural crestamoeboid cells that stream away from site of neural tube closure
neural tubeclosed hollow nerve cord
neurulaembryo in which nerve tube is separating from cutaneous ectoderm
neurulationembryonic stage in which dorsal nerve cord separates from cutaneous ectoderm
notochordrod of connective tissue that induces formation of nerve tube in chordates
organizerregion of embryo that directs a major stage of embryogenesis (i.e. gastrulation)
phenotypephysical appearance of an organism
positional informationdevelopmental directions given to cell based on its location in embryo
positional valueinformation for development of a structure based on position of cell(s)
post-transcriptional modificationchange in chemical structure of a protein after it has been synthesized
regulationability of embryo to fill in missing information to make whole embryo
mosaicisminability of embryo to fill in missing information to make whole embryo
somatic cellsnon-reproductive cells in organism
somitesbrick-like mass of mesoderm found along nerve cord and notochord
specificationcell potential restricted so it will form a characteristic structure in culture
determinationcell potential restricted so it will develop into a characteristic structure if transplanted
threshold concentrationcritical concentration above (or below) which a characteristic developmental event will occur
transcriptionprocess of DNA-dependent RNA synthesis
transcription factorsproteins that increase likelihood that RNA polymerase will bind to promoter
translationRNA-dependent protein synthesis
vegetal poleend of egg that roughly marks position of anus
zygotefertilized egg


Professor of Biology
Park University
Parkville, MO

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