| A | B |
|---|
| choline esters | acetylcholine, methacholine, carbachol, bethanechol |
| which choline esters have no nicotinic effect | methacholine, bethanechol |
| diff btwn acetylcholine and methacholine | meth resistant to ACHase, longer DOA, and acetyl has nicotinic axn (meth -none) |
| choline ester with most muscarinic action | methacholine |
| methacholine is diagnostic tool for * | belladonna poisoning |
| choline ester with more nicotinic action | carbachol |
| medical use for acetylcholine | rapid, complete, miosis during cataract removal |
| don't use bethanechol with *** | hyperthyroid, asthmatics, peptic ulcer ds |
| uses for bethanechol | urinary retention, GE reflux |
| uses for carbachol | dec intraoccular press(->glaucoma), miotic(eye sx), GI axn |
| combine with cholinergic receptors like Ach | choline esters |
| excretion of cholinomimetic alkaloids -and how hastened | kidneys; by acidirying the urine |
| cholinomimetic alkaloid most used (other than nicotine) | pilocarpine |
| diff btwn cholino alkaloids and choine esters | CNS effect with cholino alk |
| cholino alk with no nicotinic activity | muscarine |
| muscarine is assd with * | mushroom poisoning |
| new use for pilocarpine | xerostoma |
| dignostic use for pilocarpine | cystic fibrosis |
| treatment for muscarine OD | atropine |
| ADE for pilocarpine | n/v/d, salivation, sweating, vasodil, bronchoconstrict (-> contra: asthma pt) |
