| A | B |
|---|
| 3 groups of cholinesterase inhibitors | mono/bis quaternary amine alcohols, carbamates, organophosphates |
| quart amine alcohols mech of inhibition ACHase | forms bond with active center of the enzyme |
| carbamates mech of inhibition | reversible interaxn with esteratic site of ACHase; destroyed with interaxn with acetylcholine-E |
| organophosphate mech of inhibition of ACHase | binds irreversibly to esteratic site of acetylcholine-E |
| DOC for myesthenia gravis | pyridostigmine (> neo > ambenonium) |
| used for diagnosis of myesthenia gravis | edrophonium; because short DOA |
| quaternary amine alcohols | ambenonium, demecarium, derophonium |
| carbamates | neostigmine, physostigmine, pyridostigmine |
| meds for neuromusc blocade reversal | edrophonium, neostigmine |
| meds used for glaucoma | demarcarium, physostigmine, echothiophate |
| used in post-op non-obstructive urinary reten and GI ileus | neostigmine, bethanechol |
| first line tx for glaucoma | pilocarpine |
| supraventricular tachycardia may respond to * | edrophonium |
| DOC for atropine and TCA intox | physostigmine (ACHase inhibitors) |
| drug approved for mild to mod alzheimer's; has anticholinesterase and cholinomimetic axns | tacrine |
| used in insecticides and rodenticides | organophosphates, nicotine |
| most acute toxicities of nicotine | children; eating 2 cigarettes or 1 40mg drop |
| toxic effects of acute nicotine toxicity | CNS->convulsions & resp arrest, sk musc endplate depol-> resp paralysis, HTN & arrythmias |
| treatment for acute nicotine toxicity | treat symptoms: atropine, diazepam(convluse), neo and physo may not work-> intebate |
| rate nicotine is metab and excreted | rapidly |
| acute toxicity pts who survive *(how long) have good prognosis | 4 hours |
| chronic nicotine toxicity increases risk of *** | vasc ds, sudden coronary death, ulcer production |
