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AA Pharm: Cholinoceptor Blocking Drugs I

AB
"gold standard" for sea sicknessscopolomine
mydriasisdialated pupils
miosiscontracted pupils
cycloplegialoss of accomodation of pupils or near focus
effects of antimuscarinics on the eyesmydriasis, cycloplegia, dec tears
meds used clinically for eye examatropine, scopolomine, cyclopenolate, tropicamide
meds for eyes in youngatropine, scopolamine
meds for eyes in adults and older kidscyclopentolate, tropicamide
cardiovasc effect of low dose atropine-> ?pns stim & initial bradycardia
cardiovasc effect of hi dose atropine-> ?relative tachycardia
only use atropine to increase heart rate if ***hypotension, ventricular ectope are present
atropine is more dramatic in patients with **airway disease
atropine is not useful with ? patientsasthmatic
what can cause inc secretions and laryngospasmsether and ketamine
atropine can cause ? resp. symptomsbronchodilation and dec secretion
amnesia is assd with ?scopolamine
crosses BBBatropine
effects on GI and urinary system with atropine and scopolamineintestinal hypomobility and urinary retention
DOC for irritabe bowel syndromepropantheline (? and oxybutynin bcs has anticholinergenic + sm. musc and anesthetic effect)
cholinoceptor blocker that improves incontinanceoxybutynin
has less adverse effects but more expensive than oxybutynintolterodine
TCA for incontinance, but more side fximipramine
atropine effect on sweat glandssuppression, but inc body temp
atropine in large doses and repeated often is an antidote for ?cholinesterase inhibitors
general adverse effects of cholinoceptor blocking agentsdry as a bone, blind as a bat, red as abeet, mad as a hatter
effects of atropine poisoningtachycardia, delerious, hyperthermic(esp kids)
treatment for atropine poisoningtreat symptoms(best tx), physostigmine(may be dangerous), cooling blankets
antimuscarinic drugs are contraindicated in ****glaucoma, prostatic hyperplasia, ulcer pts
adverse effects of topical eye antimuscarinic medsppt glaucoma, systemic absorbtion and toxicity(so need to press on lacrimal duct)


Suzanne M. Clous

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