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Pathophysiology: Inflammation

AB
Cardinal signs of acute inflammationRedness, Swelling, Heat, Pain, Loss of Function
Increase in capillary permeabilityWhen protein rich fluid leaks into the interstitial space
Rapid vasodilation of blood vesselsCauses redness and heat
The cellular stageMovement of leukocytes to the area of injury resulting in leukocytosis
PlateletsRelease inflammatory mediators and enhance inflammatory response
Lifespan of 10 hoursNeutrophil
WBC > 10,000 mm3Bacteria infections and inflammatory processes
Immature neutrophilsBands
Play a role in chronic inflammationMonocytes
EosinophilRegulate inflammation and allergic responses
MarginationLeukocytes move to edge of capillary wall
Transmigrationleuckocytes migrate into tissues
ChemotaxisLeukocytes migrate to the site of injury
What happens during Phagocytosis?Adhere, Engulf, Kill
Serous exudateWatery fluids low in protein
Hemorrhagic exudateBloody fluid due to the leakage of RBCs from capillaries
Fibrinous exudateContains fibrinogen
Membranous exudateForm on mucous membranes and are made up of necrotic cells
Purulent exudatePus
AbsessLocalized area with fibrous wall and filled with pus
4,000mm3 - 10,000 mm3Normal WBC count
Increase in WBCLeukocytosis
InflammationNormal body response to cell and tissue injury
LymphadenitisSwelling of lymph nodes
Systemic Manifestation of InflammationFever

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