| A | B |
|---|
| alpha receptor potency series | EPI > NOR > isoproterenol; and antagonized by phentolamine and phentoxybenzamine |
| beta receptor potency series | isoproterenol > EPI > NOR ;and susceptible to blockade by propranolol |
| beta 1 receptors affects ? area(s) | heart |
| beta 2 receptors affects ? area(s) | respiratory, relax pregnant uterus |
| dopamine receptors affect ? area(s) | brain, mesentary, renal system |
| alpha receptors affect ? area(s) | vasc smooth muscle |
| adrenergic med(s) selective for alpha 1 | phenylephrine, methoxamine |
| adrenergic med(s) selective foralpha 2 | clonidine, methylnorepinephrine |
| adrenergic med(s) selective for both alpha 1 = 2 ; beta 1 > 2 | NOR |
| adrenergic med(s) selective for alpha 1 = 2; beta 1 = 2 | EPI |
| adrenergic med(s) selective for beta 1 | dobutamine |
| adrenergic med(s) selective for beta 1 = 2 | isoproterenol |
| adrenergic med(s) selective for beta 2 | terbutaline, metaproterenol, albuterol, ritodrine |
| adrenergic med(s) selective for D1=D2 | dopamine |
| mechanism of adrenergic drugs | g-protien coupled |
| effect of adrenergic drugs depends on ? | selectivity of drug to receptor, response of cells |
| receptor regulation of adrenergic drugs | alter # and fxn of receptors by: catechols, hormones, other rx, ds states |
| desensitization of adrenoceptors that occurs rapidly and transiently; receptors are temp unavail | receptor sequestration |
| desensitization of adrenoceptors that causes the actual disappearance of receptors from the surface | down-regulation |
| desensitization of adrenoceptors that impairs g-protien coupling | phosphorylation of receptor |
