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PBS Unit 3 Sickle Cell Vocabulary

AB
Blood PlasmaPale yellow fluid portion of whole blood that consists of water and its dissolved constituents (sugars, lipids, metabolic waste products, amino acids, hormones, and vitamins)
Erythrocytes (Red Blood Cells)Any of the hemoglobin-containing cells that carry oxygen to the tissues and are responsible for the red color of vertebrate blood
HematocritThe percent of the volume of whole blood that is composed of red blood cells as determined by separation of red blood cells from the plasma usually by centrifugation
Leukocytes (White Blood Cells)Any of the blood cells that are colorless, lack hemoglobin, contain a nucleus, and include lympocytes, monocytes, neutrophils, eosinophils, and basophils.
Sickle Cell DiseaseIndividuals who are homozygous for the gene controlling hemoglobin S. The disease is characterized by the destruction of red blood cells and by episodic blocking of blood vessels by the adherence of sickle cells to the vascular endothelium.
Thrombocytes (Platelets)A minute colorless disk-like body of mammalian blood that assists in blood clotting by adhering (sticking) to other platelets and to damaged epithelium. No nucleus.
AnemiaA condition in which the blood is deficient in red blood cells, in hemoglobin, or in total volume.
Amino acidOrganic monomer which is the building block of proteins.
AnticodonTriplet of nucleotide bases in transfer RNA that identifies the amino acid carried and binds to a complementary codon in messsenger RNA during protein synthesis at a ribosome.
CodonThree-nucleotide sequence of DNA or mRNA that specifies a particular amino acid or termination signal. Basic unit of the genetic code.
HydrophilicAffinity (love) of water
HydrophobicAversion (fear) of water. Tends to coalesce and form droplets in water.
Messengar RNA (mRNA)Type of RNA, synthesized from DNA and attached to ribosomes in the cytoplasm. It specifies the primary structure of a protein.
MutationChange in the DNA of a gene, ultimately creating genetic diversity.
NucleotideBuilding block of a nucleic acid. Consists of a five-carbon sugar covalently bonded to a nitrogenous base and a phosphate group.
ProteinThree dimensional polymer made of monomers of amino acids.
Protein synthesisCreation of a protein from a DNA template.
Ribonucleic Acid (RNA)Type of nucleic acid consisting of nucleotide monomers with a ribose sugar and the nitrogen bases adenine (A), cytosine (C), guannie (G), and uracil (U). Usually single stranded. Functions in protein synthesis and as the genome of some viruses.
RibosomeCell organelle that functions as the site of protein synthesis in the cytoplasm. Consists of ribosomal RNA and protein molecules and is formed by combining two subunits.
TranscriptionThe synthesis of RNA on a DNA template.
Transfer RNA (tRNA)An RNA molecule that functions as an interpreter between nucleic acid and protein language by picking up specific amino acids and recognizing the appropriate codons in mRNA
TranslationThe synthesis of a polypeptide using the genetic information encoded in an mRNA molecule. There is a change of language from nucleotides to amino acids.
AlleleAlternative form of a gene that may occur at a given locus
AutosomeChromosome that is not directly involved in determining sex, as opposed to a sex chromosome
ChromosomeAny of the usually linear bodies in the cell nucleus that contain the genetic material
Dominant traitGenetic trait that is expressed in a person who has only one copy of the gene associated with the trait. Person can have HH or Hh.
GeneUnit of hereditary information. Segment of DNA
Genetic materialMolecules responsible for heredity and variation of organisms.
GenotypeAll or part of the genetic constitution of an individual or group.
HeredityTransmission of traits from ancestor to descendant
Homologous chromosomesChromosomes having the same or allelic genes with genetic loci usually arranged in the same order.
KaryotypeDisplay of chromosome pairs of a cell arranged by size and shape
MeiosisCellular process that results in the number of chromosomes in gamete-producing cells being reduced to one half and that involves a reduction division in which one of each pair of homologous chromosomes passes to each daughter cell.
MitosisProcess that takes place in the nucleus of a dividing cell, involves a series of steps, and results in the formation of two new nuclei each having the same number of chromosomes as the parent nucleus.
PedigreeDiagram of a family tree showing the occurrence of heritable characteristics in parents and offspring over multiple generations.
PhenotypeThe observable properties of an organisms that are produced by the interaction of the genotype and the environment
Recessive traitCondition that appears only in individuals who have received two copies of a gene, one copy from each parent.
Sex chromosomeOne of the pair of chromosomes responsible for determining the sex of an individual
Punnett squareA simple graphical way of discoering all of the potential combinations of genotypes of an offspring, given the parents' genotypes.



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