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pancrelipase
Digestants: Increased digestion of fats, carbohydrates, and proteins in the GI tract
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| Trade name: | Creon, Prancreaze, pertyze, Ultresa, viokace, zenpen |
| Gerneic name: | pancrelipase |
| Use: | Increased digestion of fats, carbohydrates, and proteins in the GI tract |
| Side Effect: | FIBROSING COLONOPATHY (HIGH DOSES ONLY), abdominal pain (high doses only), D/N, stomach cramps, oral irritation, Hive, rash |
| Interactions: | Alkaline foods destroy coating on enteric-coated products, Antacids (calcium carbonate or magnesium hydroxide ) may ↓ effectiveness of pancrelipase, May ↓ the absorption of concurrently administered iron supplements |
| Dose: | Initiate with 500 lipase units/kg/meal; dose should be adjusted based on weight, clinical symptoms, and stool fat content; maximum dose = 2500 lipase units/kg/meal (or 10,000 lipase units/kg/day) |
| Nursing: | Assess patient's nutritional status (height, weight, skin-fold thickness, arm muscle circumference, and lab values); Monitor stools for high fat content (steatorrhea)-Stools will be foul-smelling and frothy; Assess patient for allergy to pork; Administer immediately before or with meals and snacks. Swallow tablets whole; do not crush, break, or chew Lab: May cause ↑ serum and urine uric acid. |
| PT teaching: | Comply with diet recommendations of HCP (generally high-calorie, high-protein, and low-fat). Dose should be adjusted for fat content of diet. If a dose is missed, it should be omitted and next dose taken with next snack, as directed. Eating immediately after taking medication helps further ensure that the medication is swallowed and does not remain in contact with mouth and esophagus for a prolonged period. Notify HCP if symptoms abdominal pain, distention, vomiting, and constipation occur. Occur more frequently with doses exceeding 6000 lipase units/kg of body weight per meal (10,000 lipase units/kg of body weight/day.) Instruct patient to notify HCP if joint pain, swelling of legs, gastric distress, or rash occurs; female patients to notify HCP if pregnancy is planned or suspected or if breast feeding. |
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