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18B streptococcus

AB
S. Pyrogenesmost serious streptococci, strict parasite, inhabits throat, nasophayrnx, occasionally skin
C-carbohydrates (s. pyrogenes)protect against lysozyme
Fimbriae (s. pyrogenes)adherence
M-protein (s. pyrogenes)contributes to resistance to phagocytosis
Hyaluronic acid capsule (s. pyrogenes)provokes no immune response
Streptolysins (s. pyrogenes)hemolysins; streptolysin O (SLO) and streptolysin S (SLS) – both cause cell and tissue injury
Erythrogenic toxin (pyrogenic) (s. pyrogenes)induces fever and typical red rash - gene for toxin carried by lysogenic phage
Superantigens (s. pyrogenes)strong monocyte and lymphocyte stimulants; cause the release of tissue necrotic factor
Streptokinase (s. pyrogenes)digests fibrin clots
Hyaluronidase (s. pyrogenes)breaks down connective tissue
DNase (s. pyrogenes)hydrolyzes DNA


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