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| Trade Name | Zofran |
| Generic Name | ondansetron |
| Use | Prevention of nausea and vomiting associated with highly or moderately emetogenic chemotherapy. PO: Prevention of nausea and vomiting associated with radiation therapy. Prevention and treatment of postoperative nausea and vomiting. |
| Contraindications | Hypersensitivity; Orally disintegrating tablets contain aspartame and should not be used in patients with phenylketonuria; Congenital long QT syndrome; Concurrent use of apomorphine. |
| Side Effects | SEROTONIN SYNDROME, headache, dizziness, drowsiness, fatigue, weakness, TORSADE DE POINTES, QT interval prolongation, constipation, diarrhea, abdominal pain, dry mouth, ↑ liver enzymes, extrapyramidal reactions, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS |
| Interactions | Use with apomorphine ↑ risk of severe hypotension and loss of consciousness; concurrent use contraindicated. Carbamazepine, phenytoin, and rifampin may ↓ levels. Drugs that affect serotonergic neurotransmitter systems, including SSRIs, SNRIs, tricyclic antidepressants, MAOIs, fentanyl, lithium, buspirone, tramadol, methylene blue, and triptans↑ risk of serotonin syndrome |
| Dosage | PO: (Adults) Prevention of nausea/vomiting associated with highly-emetogenic chemotherapy– 24 mg 30 min prior to chemotherapy. |
| Nursing Implications | Assess patient for nausea, vomiting, abdominal distention, and bowel sounds prior to and following administration. Assess patient for extrapyramidal effects (involuntary movements, facial grimacing, rigidity, shuffling walk, trembling of hands) periodically during therapy. Monitor ECG in patients with hypokalemia, hypomagnesemia, HF, bradyarrhythmias, or patients taking concomitant medications that prolong the QT interval. Monitor for signs and symptoms of serotonin syndrome, seizures, gastrointestinal symptoms |
| Teaching | take it as directed. Notify Dr if symptoms of irregular heart beat or involuntary mov. of eyes face or limbs occur |
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