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Tagamet - Histamine Receptor antagonist
Stops histamine at the H2 receptor in the gastric parietal cells, resulting in inhibition of gastric acid secretion.
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| Trade Name | Tagamet |
| Generic Name | Histamine H2 antagonists |
| Use | Treatment of duodenal ulcers and benign gastric ulcers. Treatment of heartburn, acid indigestion, and sour stomach. |
| Contraindications | Hypersensitivity. Some products may contain alcohol. Renal impairment and geriatric clients more susceptible to adverse CNS reactions. |
| Side Effects | Confusion, Dizziness, Drowsy, Arrhythmia, constipation/ diarrhea, nausea, erectile dysfunction, Agranulocytosis, Aplastic anemia |
| Interactions | Increases levels and toxicity with benzodiazapines, some beta blockers, caffeine, calcium channel blockers, SSRI, tricyclic antidepressants, sulfonureas, lidocaine, and cyclosporine. |
| Dosage | PO (adults) 300 mg four times a day for short term or 400-600mg bid. PO (child) 20-40 mg/kg/day in 4 divided doses. |
| Nursing Implications | Asses abd. pain, stool, emesis. Asses for confusion. Monitor CBC with differential. Discontinue medication before allergy testing. May cause increase in serum creatinine |
| Teaching | Take as directed. Do not take maximum dose for more than two weeks. May cause drowsiness or dizziness, caution driving. avoid alcohol and aspirin. Fluid and fiber intake will help reduce constipation. Report black tarry stools and fever. |
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