| A | B |
| Manifest Destiny | the belief that the United States should spread across the entire North American continent |
| boomtown | a town that sprang up quickly/a town that underwent rapid economic and population growth |
| frontier | the edge of a settled area |
| homestead | a settler's house and land |
| transcontinental railroad | a railroad that crosses the continent |
| pioneer | one of the first of a certain group to enter or settle a region |
| Wilderness Road | a road that Daniel Boone helped build which crossed the Cumberland Gap and let pioneers travel west across the Appalachian Mountains |
| interpreter | a person who translates from one language to another |