| A | B |
| Sacagawea | Shoshone guide and interpreter |
| Charbonneau | French fur trader married to Sacagawea |
| Corps of Discovery | Name of the Lewis and Clark expedition |
| Mandan Native Americans | Hosted Lewis and Clark first winter |
| Columbia River | Rough rapids on river last part of trip |
| York | Slave who accompanied journey |
| Seaman | Newfoundland dog on journey |
| 15$ million | Cost to buy Louisiana Purchase |
| Meriweather Lewis | Scientific leader of expedition |
| Capt. Clark | Military background helped lead expedition |
| Missouri River | Longest river traveled on expedition |
| $2,500 | Amount Congress gave to fund expedition |